A scalable, chromatography-free synthesis of benzotetramisole
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The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.
Daniels , D S B , Smith , S R , Lebl , T , Shapland , P & Smith , A D 2015 , ' A scalable, chromatography-free synthesis of benzotetramisole ' Synthesis , vol 47 , no. 1 , pp. 34-41 . DOI: 10.1055/s-0034-1378931
© Georg Thieme Verlag Stuttgart, New York. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1055/s-0034-1378931
The authors thank the Royal Society for a University Research Fellowship (ADS), the EPSRC (EP/J018139/1, DSBD), and GSK (Case award to SRS) for funding. They also thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC grant agreement number 279850 for additional funding, and the EPSRC UK National Mass Spectrometry Service Centre at Swansea University.
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