A scalable, chromatography-free synthesis of benzotetramisole
Abstract
The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.
Citation
Daniels , D S B , Smith , S R , Lebl , T , Shapland , P & Smith , A D 2015 , ' A scalable, chromatography-free synthesis of benzotetramisole ' , Synthesis , vol. 47 , no. 1 , pp. 34-41 . https://doi.org/10.1055/s-0034-1378931
Publication
Synthesis
Status
Peer reviewed
ISSN
0039-7881Type
Journal article
Description
The authors thank the Royal Society for a University Research Fellowship (ADS), the EPSRC (EP/J018139/1, DSBD), and GSK (Case award to SRS) for funding. They also thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC grant agreement number 279850 for additional funding, and the EPSRC UK National Mass Spectrometry Service Centre at Swansea University.Collections
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