Now showing items 1-19 of 19

  • All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarised cyclohexane 

    Keddie, Neil Steven; Slawin, Alexandra Martha Zoya; Lebl, Tomas; Philp, Douglas; O'Hagan, David (2015-04) - Journal article
    The highest-energy stereoisomer of 1,2,3,4,5,6-hexafluorocyclohexane, in which all of the fluorines are ‘up’, is prepared in a 12-step protocol. The molecule adopts a classic chair conformation with alternate C–F bonds ...
  • Cooperative binding in a phosphine oxide-based halogen bonded dimer drives supramolecular oligomerization 

    Maugeri, Leonardo; Lebl, Tomas; Cordes, David Bradford; Slawin, Alexandra Martha Zoya; Philp, Douglas (2017-02-17) - Journal article
    Triphenylphosphine oxide forms halogen-bonded (XB) complexes with pentafluoroiodobenzene and a 1,4-diaryl-5-iodotriazole. The stability of these complexes is assessed computationally and by 31P NMR spectroscopy in d8-toluene ...
  • The cyanobactin heterocyclase enzyme : A processive adenylase that operates with a defined order of reaction 

    Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Zollman, David; Smith, Kieran; Houssen, Wael E.; Zhu, Xiaofeng; Mann, Greg; Lebl, Tomas; Scharff, Richard; Shirran, Sally Lorna; Botting, Catherine Helen; Jaspers, Marcel; Schwarz-Linek, Uli; Naismith, Jim (2013-12) - Journal article
  • Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity 

    Pirrie, Lisa; McCarthy, Anna R.; Major, Louise L.; Morkunaite, Vaida; Zubriene, Asta; Matulis, Daumantas; Lain, Sonia; Lebl, Tomas; Westwood, Nicholas J. (2012-10) - Journal article
    The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases. Here we describe SAR studies starting ...
  • Evaluation of an olefin metathesis pre-catalyst with a bulky and electron-rich N-heterocyclic carbene 

    Manzini, Simone; Urbina Blanco, Cesar; Nelson, David James; Poater, Albert; Lebl, Tomas; Meiries, Sebastien Michel Bernard; Slawin, Alexandra Martha Zoya; Falivene, Laura; Cavallo, Luigi; Nolan, Steven Patrick (2015-03-15) - Journal article
    The commercially-available metathesis pre-catalyst M23 has been evaluated alongside new complex [RuCl2((3-phenyl)indenylidene)(PPh3)(SIPrOMe)] (1), which bears a para-methoxy-substituted N-heterocyclic carbene ligand. ...
  • Fractionation and DOSY NMR as analytical tools : from model polymers to a technical lignin 

    Montgomery, James; Lancefield, Christopher Stuart; Miles-Barrett, Daniel; Ackermann, Katrin; Bode, Bela Ernest; Westwood, Nicholas James; Lebl, Tomas (2017-11-30) - Journal article
    One key challenge hindering the valorization of lignin is its structural complexity. Artificial lignin-like materials provide a stepping stone between the simplicity of model compounds and the complexity of lignin. Here, ...
  • Geminally substituted tris(acenaphthyl) and bis(acenaphthyl) arsines, stibines and bismuthine : a structural and Nuclear Magnetic Resonance investigation 

    Chalmers, Brian Alexander; Meigh, Christina; Nejman, Phillip; Buehl, Michael; Lebl, Tomas; Woollins, J Derek; Slawin, Alexandra Martha Zoya; Kilian, Petr (2016-07-18) - Journal article
    Tris(acenaphthyl) and bis(acenaphthyl) substituted pnictogens (iPr2P-Ace)3E ( 2 – 4 ) (E = As, Sb, Bi; Ace = acenaphthene-5,6-diyl) and (iPr2P-Ace)2EPh ( 5 and 6 ), (E = As, Sb) were synthesised and fully characterised by ...
  • Integration of an active research data system with a data repository to streamline the research data lifecycle : Pure-NOMAD case study 

    Conte, Simone Ivan; Fina, Federica; Psalios, Michalis; Reyal, Shyam Mehraaj; Lebl, Tomas; Clements, Anna (2017-02-20) - Conference paper
    Research funders have introduced requirements that expect researchers to properly manage and publicly share their research data, and expect institutions to put in place services to support researchers in meeting these ...
  • Integration of an active research data system with a data repository to streamline the research data lifecycle : Pure-NOMAD case study 

    Conte, Simone Ivan; Fina, Federica; Psalios, Michalis; Reyal, Shyam Mehraaj; Lebl, Tomas; Clements, Anna (2018-04-19) - Journal article
    Research funders have introduced requirements that expect researchers to properly manage and publicly share their research data, and expect institutions to put in place services to support researchers in meeting these ...
  • Iso-seco-tanapartholides : isolation, synthesis and biological evaluation 

    Makiyi, Edward F.; Frade, Raquel F. M.; Lebl, Tomas; Jaffray, Ellis G.; Cobb, Susan E.; Harvey, Alan L.; Slawin, Alexandra M. Z.; Hay, Ronald T.; Westwood, Nicholas J. (2009-11) - Journal article
    The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-kappa B signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient ...
  • Neutral iodotriazoles as scaffolds for stable halogen-bonded assemblies in solution 

    Maugeri, Leonardo; Asencio-Hernández, Julia; Lebl, Tomas; Cordes, David Bradford; Slawin, Alexandra Martha Zoya; Delsuc, Marc-André; Philp, Douglas (2016-10-01) - Journal article
    The halogen bond (XB) donor properties of neutral 1,4-diaryl-5-iodo-1,2,3-triazoles, are explored using a combination of computational and experimental results and are shown to be competitive in halogen bonding efficiency ...
  • The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes 

    Wang, Yi; Kirsch, Peer; Lebl, Tomas; Slawin, Alexandra M. Z.; O'Hagan, David (2012-08-10) - Journal article
    Cyclododecane adopts a square-like structure with corner and edge CH2 groups. In this study erythro- and threo-1,2-difluorocyclododecanes were prepared to explore whether the two vicinal C-F bonds, with different relative ...
  • A scalable, chromatography-free synthesis of benzotetramisole 

    Daniels, David Sydney Bernard; Smith, Siobhan Rose; Lebl, Tomas; Shapland, P.; Smith, Andrew David (2015-01) - Journal article
    The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and ...
  • Structural analysis of leader peptide binding enables leader-free cyanobactin processing 

    Koehnke, Jesko Alexander Johannes Gunter; Mann, Greg; Bent, Andrew Frank; Ludewig, Hannes; Shirran, Sally Lorna; Botting, Catherine Helen; Lebl, Tomas; Houssen, Wael; Jaspers, Marcel; Naismith, Jim (2015-08) - Journal article
    Regioselective modification of amino acids within the context of a peptide is common to a number of biosynthetic pathways and many such products have potential as therapeutics. The ATP dependent enzyme LynD heterocyclizes ...
  • Structure of WbdD : a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a 

    Hagelueken, Gregor; Huang, Hexian; Clarke, Bradley R.; Lebl, Tomas; Whitfield, Chris; Naismith, James H. (2012-11) - Journal article
    The Escherichia coli serotype O9a O-antigen polysaccharide (O-PS) is a model for glycan biosynthesis and export by the ATP-binding cassette transporter-dependent pathway. The polymannose O9a O-PS is synthesized as a ...
  • The synthesis and analysis of lignin-bound Hibbert ketone structures in technical lignins 

    Miles-Barrett, Daniel; Neal, Andrew; Hand, Calum; Montgomery, James; Panovic, Isabella; Ojo, Oluwarotimi Stephen; Lancefield, Christopher Stuart; Cordes, David B.; Slawin, Alexandra M. Z.; Lebl, Tomas; Westwood, Nicholas J. (2016-11-14) - Journal article
    Understanding the structure of technical lignins resulting from acid-catalysed treatment of lignocellulosic biomass is important for their future applications. Here we report an investigation into the fate of lignin under ...
  • Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction 

    Wilkie, Ross Philip; Neal, Andrew; Johnston, Craig Andrew; Voûte, Nicholas; Lancefield, Christopher Stuart; Stell, Matthew; Medda, Federico; Makiyi, Edward Frank; Turner, Emma; Ojo, Oluwarotimi Stephen; Slawin, Alexandra Martha Zoya; Lebl, Tomas; Mullen, Peter; Harrison, David James; Ireland, Chris M; Westwood, Nicholas James (2016-09-14) - Journal article
    The synthesis of dehaloperophoramidine, a non-halogenated derivative of the marine natural product perophoramidine, is reported. The key steps included a [3,3]-Claisen rearrangement and an epoxide opening/allylsilylation ...
  • Use of bisulfite processing to generate high-β-O-4 content water-soluble lignosulfonates 

    Miles-Barrett, Daniel M.; Montgomery, James R. D.; Lancefield, Christopher S.; Cordes, David B.; Slawin, Alexandra M. Z.; Lebl, Tomas; Carr, Reuben; Westwood, Nicholas J. (2017-02-06) - Journal article
    With lignin-first biorefineries likely to become a reality, controlled depolymerization of high-quality lignin streams to high value products has become a priority. Using bisulfite chemistry, access to a high-β-O-4 content ...
  • The use of residual dipolar coupling for conformational analysis of structurally related natural products 

    Lancefield, Christopher Stuart; Slawin, Alexandra Martha Zoya; Westwood, Nicholas James; Lebl, Tomas (2015-06) - Journal article
    Determining the conformational preferences of molecules in solution remains a considerable challenge. Recently, the use of residual dipolar coupling (RDC) analysis has emerged as a key method to address this. Whilst to ...