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A scalable, chromatography-free synthesis of benzotetramisole

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dc.contributor.authorDaniels, David Sydney Bernard
dc.contributor.authorSmith, Siobhan Rose
dc.contributor.authorLebl, Tomas
dc.contributor.authorShapland, P.
dc.contributor.authorSmith, Andrew David
dc.date.accessioned2015-11-21T00:11:40Z
dc.date.available2015-11-21T00:11:40Z
dc.date.issued2015-01
dc.identifier167925905
dc.identifierd9b6a498-f064-456f-9e2c-ef6b24271c28
dc.identifier84911940420
dc.identifier000347380200003
dc.identifier.citationDaniels , D S B , Smith , S R , Lebl , T , Shapland , P & Smith , A D 2015 , ' A scalable, chromatography-free synthesis of benzotetramisole ' , Synthesis , vol. 47 , no. 1 , pp. 34-41 . https://doi.org/10.1055/s-0034-1378931en
dc.identifier.issn0039-7881
dc.identifier.otherORCID: /0000-0002-2104-7313/work/36567504
dc.identifier.otherORCID: /0000-0002-0269-3221/work/48131701
dc.identifier.urihttps://hdl.handle.net/10023/7827
dc.descriptionThe authors thank the Royal Society for a University Research Fellowship (ADS), the EPSRC (EP/J018139/1, DSBD), and GSK (Case award to SRS) for funding. They also thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC grant agreement number 279850 for additional funding, and the EPSRC UK National Mass Spectrometry Service Centre at Swansea University.en
dc.description.abstractThe scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.
dc.format.extent762195
dc.language.isoeng
dc.relation.ispartofSynthesisen
dc.subjectIsothioureaen
dc.subjectLewis base catalysisen
dc.subjectAsymmetric catalysisen
dc.subjectKinetic resolutionen
dc.subjectRearrangementen
dc.subjectBenzotetramisoleen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleA scalable, chromatography-free synthesis of benzotetramisoleen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1055/s-0034-1378931
dc.description.statusPeer revieweden
dc.date.embargoedUntil2015-11-21
dc.identifier.urlhttps://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1378931#supmaten
dc.identifier.grantnumberEP/J018139/1en
dc.identifier.grantnumberEP/J018139/1en


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