Now showing items 1-3 of 3

  • Applications of isothiourea generated ammonium enolates in asymmetric synthesis 

    Smith, Siobhan Rose (University of St Andrews, 2014) - Thesis
    This thesis describes expansion of the ability of isothioureas to act as organocatalysts in formal [2+2]-, [3+2]- and [4+2]-cycloadditions between carboxylic acids and various acceptors via Type I ammonium enolate ...
  • Asymmetric isothiourea-catalysed formal [3+2] cycloadditions of ammonium enolates with oxaziridines 

    Smith, Siobhan Rose; Fallan, Charlene; Taylor, James Edward; McLennan, Ross Sinclair; Daniels, David Sydney Bernard; Morrill, Louis Christian; Slawin, Alexandra Martha Zoya; Smith, Andrew David (2015-07-13) - Journal article
    A highly enantioselective Lewis base-catalysed formal [3+2] cycloaddition of ammonium enolates and oxaziridines to give stereodefined oxazolidin-4-ones in high yield is described. Employing an enantioenriched oxaziridine ...
  • A scalable, chromatography-free synthesis of benzotetramisole 

    Daniels, David Sydney Bernard; Smith, Siobhan Rose; Lebl, Tomas; Shapland, P.; Smith, Andrew David (2015-01) - Journal article
    The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and ...