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Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

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Date
12/2015
Author
Wang, Yanghua
Gersten, Adam
Moleirinho, Susana
Gunn-Moore, Frank
Reynolds, Paul Andrew
Prystowsky, Michael
Keywords
Squamous cell carcinoma
perineural invasion
YAP expression
fibroblast
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
NDAS
Metadata
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Abstract
We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.
Citation
Wang , Y , Gersten , A , Moleirinho , S , Gunn-Moore , F , Reynolds , P A & Prystowsky , M 2015 , ' Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression ' , Academic Pathology , vol. 2 , no. 4 . https://doi.org/10.1177/2374289515616972
Publication
Academic Pathology
Status
Peer reviewed
DOI
https://doi.org/10.1177/2374289515616972
ISSN
2374-2895
Type
Journal article
Rights
Copyright The Authors 2015. Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Description
Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/7880

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