Now showing items 1-11 of 11

    • Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells 

      Tilston-Lunel, Andrew Martin; Haley, Kathryn; Schlecht, Nicolas; Wang, Yanhua; Chatterton, Abigail Louise Dougal; Moleirinho, Susana Luisa; Watson, Ailsa; Hundal, Harinder; Prystowsky, Michael; Gunn-Moore, Francis James; Reynolds, Paul Andrew (2016-10) - Journal article
      Crumbs3 (CRB3) is a component of epithelial junctions that has been implicated in apical-basal polarity, apical identity, apical stability, cell adhesion and cell growth. CRB3 undergoes alternative splicing to yield two ...
    • Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression 

      Wang, Yanghua; Gersten, Adam; Moleirinho, Susana; Gunn-Moore, Frank; Reynolds, Paul Andrew; Prystowsky, Michael (2015-12) - Journal article
      We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts ...
    • Glutaminase inhibition in renal cell carcinoma therapy 

      Raczka, Aleksandra Maria; Reynolds, Paul Andrew (2019-05-14) - Journal item
      Receptor tyrosine kinase inhibitors have been a standard first-line therapy for renal cell carcinoma (RCC) for over a decade. Although they stabilize the disease, they are unable to remove all tumor cells, leading to ...
    • Human tissue in systems medicine 

      Caie, Peter David; Schuur, Klaas; Oniscu, Anca; Mullen, Peter; Reynolds, Paul Andrew; Harrison, David James (2013-12) - Journal item
      Histopathology, the examination of an architecturally artefactual, two dimensional, static image remains a potent tool allowing diagnosis and empirical expectation of prognosis. Considerable optimism exists that the advent ...
    • Identification of novel podocyte stress-response mechanisms in vitro 

      Haley, Kathryn (University of St Andrews, 2018) - Thesis
    • Mammalian upstream Hippo signalling pathway proteins activate core pathway kinases and functionally antagonize oncogenic YAP 

      Moleirinho, Susana (University of St Andrews, 2013-06-26) - Thesis
      The mechanism of body and organ size control is an unsolved puzzle. Initially characterized in Drosophila melanogaster, the Salvador/Warts/Hippo (Hippo) signalling pathway, highly conserved throughout evolution, defines a ...
    • Podocyte injury elicits loss and recovery of cellular forces 

      Haley, Kathryn; Kronenberg, Nils Michael; Liehm, Philipp; Elshani, Mustafa; Bell, Cameron; Harrison, David James; Gather, Malte Christian; Reynolds, Paul Andrew (2018-06-27) - Journal article
      In the healthy kidney, specialized cells called podocytes form a sophisticated blood filtration apparatus that allows excretion of wastes and excess fluid from the blood while preventing loss of proteins such as albumin. ...
    • Polycomb proteins and breast cancer 

      Fedele, Vita (University of St Andrews, 2012) - Thesis
      In the Western world, breast cancer is the most frequent malignancy in women and still the leading cause of cancer related deaths, therefore, a better understanding of the disease is needed. Adequate therapeutic targets ...
    • Title redacted 

      Gasparoli, Federico Maria (University of St Andrews, 2018-12-06) - Thesis
    • Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts 

      Moleirinho, Susan; Patrick, Calum; Tilston-Lunel, Andrew Martin; Higginson, JR; Angus, Liselotte; Antkowiak, Maciej; Barnett, Susan; Prystowsky, Michael; Reynolds, Paul Andrew; Gunn-Moore, Frank J (2013-04-08) - Journal article
      Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation ...
    • Willing to be involved in cancer 

      Gunn-Moore, Francis James; Tilston-Lunel, Andrew Martin; Reynolds, Paul Andrew (2016-07-18) - Journal item
      Genome sequencing is now a common procedure, but prior to this, screening experiments using protein baits was one of the routinely used methods that, occasionally, allowed the identification of new gene products. One such ...