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dc.contributor.authorWang, Yanghua
dc.contributor.authorGersten, Adam
dc.contributor.authorMoleirinho, Susana
dc.contributor.authorGunn-Moore, Frank
dc.contributor.authorReynolds, Paul Andrew
dc.contributor.authorPrystowsky, Michael
dc.date.accessioned2015-12-02T11:40:14Z
dc.date.available2015-12-02T11:40:14Z
dc.date.issued2015-12
dc.identifier226915841
dc.identifier1f691b8f-c1d8-46ee-9e11-33df24c1b10b
dc.identifier85050650464
dc.identifier000433766000004
dc.identifier.citationWang , Y , Gersten , A , Moleirinho , S , Gunn-Moore , F , Reynolds , P A & Prystowsky , M 2015 , ' Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression ' , Academic Pathology , vol. 2 , no. 4 . https://doi.org/10.1177/2374289515616972en
dc.identifier.issn2374-2895
dc.identifier.otherORCID: /0000-0001-8738-1245/work/34034578
dc.identifier.otherORCID: /0000-0003-3422-3387/work/34730418
dc.identifier.urihttps://hdl.handle.net/10023/7880
dc.descriptionPaul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.en
dc.description.abstractWe retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.
dc.format.extent5
dc.format.extent1184348
dc.format.extent700652
dc.language.isoeng
dc.relation.ispartofAcademic Pathologyen
dc.subjectSquamous cell carcinomaen
dc.subjectperineural invasionen
dc.subjectYAP expressionen
dc.subjectfibroblasten
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0254en
dc.titleFibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expressionen
dc.typeJournal articleen
dc.contributor.sponsorThe Melville Trust for the Care & Cureen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1177/2374289515616972
dc.description.statusPeer revieweden
dc.identifier.grantnumberM00109.0001/RG/JGCen


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