Now showing items 1-20 of 115

  • 5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer 

    Uribe-Lewis, Santiago; Stark, Rory; Carroll, Thomas; Dunning, Mark J.; Bachman, Martin; Ito, Yoko; Stojic, Lovorka; Halim, Silvia; Vowler, Sarah L.; Lynch, Andy G.; Delatte, Benjamin; de Bony, Eric J.; Colin, Laurence; Defrance, Matthieu; Krueger, Felix; Silva, Ana Luisa; ten Hoopen, Rogier; Ibrahim, Ashraf E.K.; Fuks, François; Murrell, Adele (2015-04-01) - Journal article
    Background : The discovery of cytosine hydroxymethylation (5hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behaviour in colon cancer. 5hmC is ...
  • 5-hydroxymethylcytosine profiling as an indicator of cellular state 

    Laird, Alexander; Thomson, John P.; Harrison, David J.; Meehan, Richard R. (2013-12) - Journal article
    DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including ...
  • ABC of breast disease : Breast cancer-epidemiology, risk factors, and genetics 

    McPherson, K; Steel, C M; Dixon, J M (2000-09-09) - Journal item
  • Antitumour activity of the novel flavonoid oncamex in preclinical breast cancer models 

    Martínez-Pérez, Carlos; Ward, Carol; Turnbull, Arran K; Mullen, Peter; Cook, Graham; Meehan, James; Jarman, Edward J; Thomson, Patrick I T; Campbell, Colin J; McPhail, Donald; Harrison, David James; Langdon, Simon P (2016-04-13) - Journal article
    Background: The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved cell uptake and ...
  • Apoptosis and DNA methylation 

    Meng, Huan X; Hackett, James A; Nestor, Colm; Dunican, Donncha S; Madej, Monika; Reddington, James P; Pennings, Sari; Harrison, David J; Meehan, Richard R (2011-04-01) - Journal article
    Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone ...
  • Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data 

    Camacho, Niedzica; Van Loo, Peter; Edwards, Sandra; Kay, Jonathan D.; Matthews, Lucy; Haase, Kerstin; Clark, Jeremy; Dennis, Nening; Thomas, Sarah; Kremeyer, Barbara; Zamora, Jorge; Butler, Adam P.; Gundem, Gunes; Merson, Sue; Luxton, Hayley; Hawkins, Steve; Ghori, Mohammed; Marsden, Luke; Lambert, Adam; Karaszi, Katalin; Pelvender, Gill; Massie, Charlie E.; Kote-Jarai, ZSofia; Raine, Keiran; Jones, David; Howat, William J.; Hazell, Steven; Livni, Naomi; Fisher, Cyril; Ogden, Christopher; Kumar, Pardeep; Thompson, Alan; Nicol, David; Mayer, Erik; Dudderidge, Tim; Yu, Yongwei; Zhang, Hongwei; Shah, Nimish C.; Gnanapragasam, Vincent J.; Group, The CRUK-ICGC Prostate; Isaacs, William; Visakorpi, Tapio; Hamdy, Freddie; Berney, Dan; Verrill, Clare; Warren, Anne Y.; Wedge, David C.; Lynch, Andrew G.; Foster, Christopher S.; Lu, Yong Jie; Bova, G. Steven; Whitaker, Hayley C.; McDermott, Ultan; Neal, David E.; Eeles, Rosalind; Cooper, Colin S.; Brewer, Daniel S. (2017-09-25) - Journal article
    A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
  • Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents 

    Gallina, Maria Elena; Zhou, Yu; Johnson, Christopher J; Harris-Birtill, David; Singh, Mohan; Zhao, Hailin; Ma, Daqing; Cass, Tony; Elson, Daniel S (2016-02-01) - Journal article
    GNRs are emerging as a new class of probes for theradiagnostic applications thanks to their unique optical properties. However, the achievement of proper nanoconstructs requires the synthesis of highly pure GNRs with ...
  • ARID3B: a novel regulator of the Kaposi’s sarcoma-associated herpesvirus lytic cycle 

    Wood, Jennifer; Boyne, James; Paulus, Christina; Jackson, Brian; Nevels, Michael Martin; Whitehouse, Adrian; Hughes, David John (2016-10) - Journal article
    KSHV is the causative agent of commonly fatal malignancies of immuno-compromised individuals, including primary effusion lymphoma (PEL) and Kaposi’s sarcoma (KS). A hallmark of all herpesviruses is their biphasic lifecycle ...
  • Association of human papillomavirus 16 E2 with Rad50-interacting protein 1 enhances viral DNA replication 

    Campos-León, Karen; Wijendra, Kalpanee; Siddiqa, Abida; Pentland, Ieisha; Feeney, Katherine M.; Knapman, Alison; Davies, Rachel; Androphy, Elliot J.; Parish, Joanna L. (2017-03) - Journal article
    Rad50-interacting protein 1 (Rint1) associates with the DNA damage response protein Rad50 during the transition from the S phase to the G2/M phase and functions in radiation-induced G2 checkpoint control. It has also been ...
  • Authentication and characterisation of a new oesophageal adenocarcinoma cell line : MFD-1 

    Garcia, Edwin; Hayden, Annette; Birts, Charles; Britton, Edward; Cowie, Andrew; Pickard, Karen; Mellone, Massimiliano; Choh, Clarisa; Derouet, Mathieu; Duriez, Patrick; Noble, Fergus; White, Michael J.; Primrose, John N.; Strefford, Jonathan C.; Rose-Zerilli, Matthew; Thomas, Gareth J.; Ang, Yeng; Sharrocks, Andrew D.; Fitzgerald, Rebecca C.; Underwood, Timothy J.; Lynch, Andy G. (2016-09-07) - Journal article
    New biological tools are required to understand the functional significance of genetic events revealed by whole genome sequencing (WGS) studies in oesophageal adenocarcinoma (OAC). The MFD-1 cell line was isolated from a ...
  • Barriers and facilitators to smoking cessation in a cancer context : a qualitative study of patient, family and professional views 

    Wells, Mary; Aitchison, Patricia; Harris, Fiona; Ozakinci, Gozde; Radley, Andrew; Bauld, Linda; Entwistle, Vikki; Munro, Alastair John; Haw, Sally; Culbard, Bill; Williams, Brian (2017-05-19) - Journal article
    Background Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. ...
  • Bifurcations and chaotic dynamics in a tumour-immune-virus system 

    Eftimie, R.; Macnamara, C. K.; Dushoff, Jonathan; Bramson, J. L.; Earn, D. J. D. (2016-12-07) - Journal article
    Despite mounting evidence that oncolytic viruses can be effective in treating cancer, understanding the details of the interactions between tumour cells, oncolytic viruses and immune cells that could lead to tumour control ...
  • Biosynthesis of magnetic nanoparticles by human mesenchymal stem cells following transfection with the magnetotactic bacterial gene mms6 

    Elfick, Alistair; Rischitor, Grigore; Mouras, Rabah; Azfer, Asim; Lungaro, Lisa; Uhlarz, Marc; Herrmannsdörfer, Thomas; Lucocq, John Milton; Gamal, Wesam; Bagnaninchi, Pierre; Semple, Scott; Salter, Donald M. (2017-01-04) - Journal article
    The use of stem cells to support tissue repair is facilitated by loading of the therapeutic cells with magnetic nanoparticles (MNPs) enabling magnetic tracking and targeting. Current methods for magnetizing cells use ...
  • Bystander effects and their implications for clinical radiation therapy : insights from multiscale in silico experiments 

    Powathil, Gibin; Munro, Alastair John; Chaplain, Mark Andrew Joseph; Swat, Maciej (2016-07-21) - Journal article
    Radiotherapy is a commonly used treatment for cancer and is usually given in varying doses. At low radiation doses relatively few cells die as a direct response to radiation but secondary radiation effects, such as DNA ...
  • C35 overexpression defines subsets of human breast cancer and its immunoreceptor tyrosine-based activation motif represents a novel treatment target 

    Katz, E.; Faratian, D.; Bartlett, J. M. S.; MacLeod, K.; Pedersen, H.; Larionov, A.; Smith, E. M.; Howell, A. P.; Dixon, J. M.; Evans, E. E.; Langdon, S. P.; Harrison, D. J. (2008-05-13) - Journal item
  • Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults 

    Anderson, Richard A; Mitchell, Rod T; Kelsey, Thomas W; Spears, Norah; Telfer, Evelyn E; Wallace, W Hamish B (2015-07) - Journal article
    Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment.. The loss of an opportunity for fertility is a prime concern in both male and ...
  • CCCTC-binding factor recruitment to the early region of the human papillomavirus type 18 genome regulates viral oncogene expression 

    Paris, Christian; Pentland, Ieisha; Groves, Ian; Roberts, David C; Powis, Simon J; Coleman, Nicholas; Roberts, Sally; Parish, Joanna L (2015-05) - Journal article
    Host cell differentiation-dependent regulation of human papillomavirus (HPV) gene expression is required for productive infection. The host cell CCCTC-binding factor (CTCF) functions in genome-wide chromatin organization ...
  • Cell population heterogeneity and evolution towards drug resistance in cancer : biological and mathematical assessment, theoretical treatment optimisation 

    Chisholm, Rebecca H.; Lorenzi, Tommaso; Clairambault, Jean (2016-11) - Journal article
    Background. Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying expression of ...
  • Chemical analysis of multicellular tumour spheroids 

    Jamieson, L.E.; Harrison, David James; Campbell, C.J. (2015-06-21) - Journal article
    Conventional two dimensional (2D) monolayer cell culture has been considered the ‘gold standard’ technique for in vitro cellular experiments. However, the need for a model that better mimics the three dimensional (3D) ...
  • Client and practitioner perspectives on the screening mammography experience 

    Whelehan, P.; Evans, A.; Ozakinci, G. (2017-05) - Journal article
    Mammography is often painful and unpleasant, but effective interventions to improve the experience remain scarce. As a first step towards more effective interventions, we aimed to achieve a thorough, contemporary understanding ...