Utilising proteomic approaches to understand oncogenic human herpesviruses (Review)
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The γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. These viruses persist for the life of the host and may each contribute to a number of malignancies, for which there are currently no cures. Large-scale proteomic-based approaches provide an excellent means of increasing the collective understanding of the proteomes of these complex viruses and elucidating their numerous interactions within the infected host cell. These large-scale studies are important for the identification of the intricacies of viral infection and the development of novel therapeutics against these two important pathogens.
Owen , C B , Hughes , D J , Baquero-Perez , B , Berndt , A , Schumann , S , Jackson , B R & Whitehouse , A 2014 , ' Utilising proteomic approaches to understand oncogenic human herpesviruses (Review) ' Molecular and Clinical Oncology , vol. 2 , no. 6 , pp. 891-903 . DOI: 10.3892/mco.2014.341
Molecular and Clinical Oncology
© 2014. Spandidos Publications. All rights reserved.
DescriptionThis study was supported in part by BBSRC, YCR, Wellcome Trust and AICR.
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