Now showing items 1-7 of 7

    • Acetylation site specificities of lysine deacetylase inhibitors in human cells 

      Schölz, Christian; Weinert, Brian T.; Wagner, Sebastian A.; Beli, Petra; Miyake, Yasuyuki; Qi, Yun; Jensen, Lars J.; Streicher, Werner; McCarthy, Anna Rose; Westwood, Nicholas James; Lain, Sonya; Cox, Jürgen; Matthias, Patrick; Mann, Matthias; Bradner, James E.; Choudhary, Chunaram (2015) - Journal article
      Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely ...
    • Animal origin of 13th-century uterine vellum revealed using noninvasive peptide fingerprinting 

      Fiddyment, Sarah; Holsinger, Bruce; Ruzzier, Chiara; Devine, Alexander; Binois, Annelise; Albarella, Umberto; Fischer, Roman; Nichols, Emma; Curtis, Antoinette; Cheese, Edward; Teasdale, Matthew D.; Checkley-Scott, Caroline; Milner, Stephen J.; Rudy, Kathryn Margaret; Johnson, Eric J.; Vnouček, Jiří; Garrison, Mary; McGrory, Simon; Bradley, Daniel G.; Collins, Matthew J. (2015-12-08) - Journal article
      Tissue-thin parchment made it possible to produce the first pocket Bibles: Thousands were made in the 13th century. The source of this parchment, often called “uterine vellum,” has been a long-standing controversy in ...
    • Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies 

      Brown, Sharon J.; Fuller, Heidi R.; Jones, Philip; Caterson, Bruce; Shirran, Sally L.; Botting, Catherine H.; Roberts, Sally (2017-02) - Journal article
      This paper reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and are expected to have been ...
    • Differential reactivity of closely related zinc(II)-binding metallothioneins from the plant Arabidopsis thaliana 

      Imam, Hasan T.; Blindauer, Claudia A. (2018-01) - Journal article
      The dynamics of metal binding to and transfer from metalloproteins involved in metal homeostasis are important for understanding cellular distribution of metal ions. The dicotyledonous plant Arabidopsis thaliana has two ...
    • Lipidomic investigations into the phospholipid content and metabolism of various kinetoplastids 

      Roberts, Matthew D. (University of St Andrews, 2017-06-21) - Thesis
      This work expands the knowledge on phospholipid metabolism in the kinetoplastid parasites: T. brucei, T. cruzi, Leishmania spp. that cause neglected tropical diseases and the related non-human pathogenic Crithidia ...
    • The major histocompatibility complex class I immunopeptidome of extracellular vesicles 

      Synowsky, Silvia A.; Shirran, Sally L.; Cooke, Fiona G. M.; Antoniou, Antony N.; Botting, Catherine H.; Powis, Simon J. (2017-10-13) - Journal article
      Extracellular vesicles (EVs) are released by most cell types and have been associated with multiple immunomodulatory functions. MHC class I molecules have crucial roles in antigen presentation and in eliciting immune ...
    • Utilising proteomic approaches to understand oncogenic human herpesviruses (Review) 

      Owen, Christopher B; Hughes, David J; Baquero-Perez, Belinda; Berndt, Anja; Schumann, Sophie; Jackson, Brian R; Whitehouse, Adrian (2014-11) - Journal article
      The γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. These viruses persist for the life of the host and may ...