Now showing items 1-17 of 17

    • Acetylation site specificities of lysine deacetylase inhibitors in human cells 

      Schölz, Christian; Weinert, Brian T.; Wagner, Sebastian A.; Beli, Petra; Miyake, Yasuyuki; Qi, Yun; Jensen, Lars J.; Streicher, Werner; McCarthy, Anna Rose; Westwood, Nicholas James; Lain, Sonya; Cox, Jürgen; Matthias, Patrick; Mann, Matthias; Bradner, James E.; Choudhary, Chunaram (2015) - Journal article
      Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely ...
    • Comparative proteomics implicates a role for multiple secretion systems in electrode-respiring Geobacter sulfurreducens biofilms 

      Kavanagh, Paul; Botting, Catherine H.; Jana, Partha S.; Leech, Dónal; Abram, Florence (2016-12-02) - Journal article
      Geobacter sulfurreducens is a dissimilatory metal-reducing bacterium capable of forming thick electron-conducting biofilms on solid electrodes. Here, we employ for the first time comparative proteomics to identify key ...
    • Comparative transcriptomics and proteomics of three different aphid species identifies core and diverse effector sets 

      Thorpe, Peter; Cock, Peter J A; Bos, Jorunn (2016-03-02) - Journal article
      BACKGROUND: Aphids are phloem-feeding insects that cause significant economic losses to agriculture worldwide. While feeding and probing these insects deliver molecules, called effectors, inside their host to enable ...
    • Direct and indirect approaches to identify drug modes of action 

      Tulloch, Lindsay B.; Menzies, Stefanie K.; Coron, Ross P.; Roberts, Matthew D.; Florence, Gordon J.; Smith, Terry K. (2018-01) - Journal item
      Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drug target diversity as lead compounds identified through such screens are not limited to known targets. While increasing ...
    • Extensive lysine methylation in hyperthermophilic crenarchaea : potential implications for protein stability and recombinant enzymes 

      Botting, Catherine H.; Talbot, Paul; Paytubi, Sonia; White, Malcolm F. (2010) - Journal article
      In eukarya and bacteria, lysine methylation is relatively rare and is catalysed by sequence-specific lysine methyltransferases that typically have only a single-protein target. Using RNA polymerase purified from the ...
    • The genome of the obligate intracellular parasite Trachipleistophora hominis : new insights into microsporidian genome dynamics and reductive evolution 

      Heinz, Eva; Williams, Tom A.; Nakjang, Sirintra; Noel, Christophe J.; Swan, Daniel C.; Goldberg, Alina V.; Harris, Simon R.; Weinmaier, Thomas; Markert, Stephanie; Becher, Doerte; Bernhardt, Joerg; Dagan, Tal; Hacker, Christian; Lucocq, John Milton; Schweder, Thomas; Rattei, Thomas; Hall, Neil; Hirt, Robert P.; Embley, T. Martin (2012-10-25) - Journal article
      The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems involving obligate intracellular bacteria. Here we present 8.5 Mb ...
    • Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence 

      Faratian, Dana; Christiansen, Jason; Gustavson, Mark; Jones, Christine; Scott, Christopher; Um, InHwa; Harrison, David J (2011-10-25) - Journal article
      Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, ...
    • Human interactome of the influenza B virus NS1 protein 

      Patzina, Corinna; Botting, Catherine H.; García-Sastre, Adolfo; Randall, Richard E.; Hale, Benjamin G. (2017-09-01) - Journal article
      NS1 proteins of influenza A and B viruses share limited sequence homology, yet both are potent manipulators of host cell processes, particularly interferon (IFN) induction. Although many cellular partners are reported for ...
    • The identification and investigation of neurochondrin as a novel interactor of the survival of motor neuron protein, through analysis of the interactomes of Sm family proteins and cell fractionation 

      Thompson, Luke (University of St Andrews, 2018-06-27) - Thesis
      Spinal Muscular Atrophy (SMA) is a neurodegenerative, inherited disease caused by an insufficient amount of functional Survival of Motor Neurone protein (SMN), though the exact mechanism underlying this is not fully ...
    • Investigating the foot-and-mouth disease virus 3A protein 

      Howes, Emma Louise (University of St Andrews, 2018) - Thesis
      Foot-and-Mouth Disease Virus (FMDV) is a globally important pathogen responsible for causing Foot-and-Mouth Disease (FMD) in wildlife and domestic livestock species and has significant economic impacts. FMD is difficult ...
    • The major histocompatibility complex class I immunopeptidome of extracellular vesicles 

      Synowsky, Silvia A.; Shirran, Sally L.; Cooke, Fiona G. M.; Antoniou, Antony N.; Botting, Catherine H.; Powis, Simon J. (2017-10-13) - Journal article
      Extracellular vesicles (EVs) are released by most cell types and have been associated with multiple immunomodulatory functions. MHC class I molecules have crucial roles in antigen presentation and in eliciting immune ...
    • Not just fat : investigating the proteome of cetacean blubber tissue 

      Kershaw, Joanna Louise; Botting, Catherine Helen; Brownlow, Andrew; Hall, Ailsa Jane (2018) - Journal article
      Mammalian adipose tissue is increasingly being recognized as an endocrine organ involved in the regulation of a number of metabolic processes and pathways. It responds to signals from different hormone systems and the ...
    • The Scottish Structural Proteomics Facility : targets, methods and outputs 

      Oke, M; Carter, LG; Johnson, KA; Liu, H; McMahon, SA; Yan, X; Kerou, M; Weikart, ND; Kadi, N; Sheikh, MA; Schmelz, S; Dorward, M; Zawadzki, M; Cozens, C; Falconer, H; Powers, H; Overton, IM; van Niekerk, CA; Peng, X; Patel, P; Garrett, RA; Prangishvili, D; Botting, CH; Coote, PJ; Dryden, DT; Barton, GJ; Schwarz-Linek, Uli; Challis, GL; Taylor, GL; White, MF; Naismith, JH (2010-06-01) - Journal article
      The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures ...
    • Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development 

      Fuller, Heidi; Mandefro, Berhan; Shirran, Sally Lorna; Gross, Andrew; Kaus, Anjoscha; Botting, Catherine Helen; Morris, Glen; Sareen, Dhruv (2016-01-11) - Journal article
      Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the ...
    • Stathmin is enriched in the developing corticospinal tract 

      Fuller, Heidi; Slade, Robert; Jovanov-Milošević, Nataša; Babić, Mirjana; Sedmak, Goran; Šimić, Goran; Fuszard, Matthew Alexander; Shirran, Sally Lorna; Botting, Catherine Helen; Gates, Monte (2015) - Journal article
      Understanding the intra- and extracellular proteins involved in the development of the corticospinal tract (CST) may offer insights into how the pathway could be regenerated following traumatic spinal cord injury. Currently, ...
    • TarO : a target optimisation system for structural biology 

      Overton, I M; van Niekerk, C A; Carter, L G; Dawson, A; Martin, D M; Cameron, S; McMahon, S A; White, Malcolm F; Hunter, W N; Naismith, Jim; Barton, G J (2008-07) - Journal article
      TarO (http://www.compbio.dundee.ac.uk/taro) offers a single point of reference for key bioinformatics analyses relevant to selecting proteins or domains for study by structural biology techniques. The protein sequence is ...
    • Utilising proteomic approaches to understand oncogenic human herpesviruses (Review) 

      Owen, Christopher B; Hughes, David J; Baquero-Perez, Belinda; Berndt, Anja; Schumann, Sophie; Jackson, Brian R; Whitehouse, Adrian (2014-11) - Journal article
      The γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. These viruses persist for the life of the host and may ...