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5-hydroxymethylcytosine profiling as an indicator of cellular state

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laird2013epigenomics655.pdf (3.015Mb)
Date
12/2013
Author
Laird, Alexander
Thomson, John P.
Harrison, David J.
Meehan, Richard R.
Keywords
Cancer
Cellular state
Epigenetics
Hydroxymethylcytosine
Embryonic stem-cells
Active DNA demethylation
Acetylglucosamine transferase OGT
Isocitrate dehydrogenase 1
Acute myeloid-leukemia
Base excision-repair
Mouse-liver tumors
TET proteins
Thymine DNA
Human cancers
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
QH426 Genetics
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Abstract
DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydroxymethylcytosine and, with this, greater insight into the distribution, regulation and function of this mark, which are reviewed here. Better understanding of the associated pathways involved in regulation of, and by, 5-hydroxymethylcytosine may give promise to new therapeutic targets. We discuss evidence to support the view of 5-hydroxymethylcytosine as a unique and dynamic mark of cellular state. These 5-hydroxymethylcytosine profiles may offer optimism for the development of diagnostic, prognostic and predictive biomarkers.
Citation
Laird , A , Thomson , J P , Harrison , D J & Meehan , R R 2013 , ' 5-hydroxymethylcytosine profiling as an indicator of cellular state ' , Epigenomics , vol. 5 , no. 6 , pp. 655-669 . https://doi.org/10.2217/epi.13.69
Publication
Epigenomics
Status
Peer reviewed
DOI
https://doi.org/10.2217/epi.13.69
ISSN
1750-1911
Type
Journal article
Rights
© Richard R Meehan et al. This work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0
Description
A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer. J Thomson is supported by the MARCAR project. Work in RR Meehan’s laboratory is supported by the Medical Research Council, the BBSRC and by the Innovative Medicine Initiative Joint Undertaking (IMI JU) under grant agreement number 115001 (MARCAR project).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/5157

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