Now showing items 1-4 of 4

  • 5-hydroxymethylcytosine profiling as an indicator of cellular state 

    Laird, Alexander; Thomson, John P.; Harrison, David J.; Meehan, Richard R. (2013-12) - Journal article
    DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including ...
  • An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer 

    Katz, Elad; Dubois-Marshall, Sylvie; Sims, Andrew H.; Gautier, Philippe; Caldwell, Helen; Meehan, Richard R.; Harrison, David J. (2011-02-15) - Journal article
    The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility. In human breast ...
  • Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes 

    Nestor, Colm E.; Ottaviano, Raffaele; Reddington, James; Sproul, Duncan; Reinhardt, Diana; Dunican, Donncha; Katz, Elad; Dixon, J. Michael; Harrison, David James; Meehan, Richard R. (2012-03) - Journal article
    The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our ...
  • Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer 

    Sproul, Duncan; Nestor, Colm; Culley, Jayne; Dickson, Jacqueline H.; Dixon, J. Michael; Harrison, David James; Meehan, Richard R.; Sims, Andrew H.; Ramsahoye, Bernard H. (2011-03-15) - Journal article
    Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this mechanism to contribute to tumor development depends on whether the genes affected are repressed because of their methylation. ...