Now showing items 1-6 of 6

  • 5-hydroxymethylcytosine profiling as an indicator of cellular state 

    Laird, Alexander; Thomson, John P.; Harrison, David J.; Meehan, Richard R. (2013-12) - Journal article
    DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including ...
  • Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome 

    Laird, Alexander; O'Mahony, Fiach C.; Nanda, Jyoti; Riddick, Antony C. P.; O'Donnell, Marie; Harrison, David J.; Stewart, Grant D. (2013-04-05) - Journal article
    Renal cell carcinoma (RCC) is the most deadly of urological malignancies. Metastatic disease affects one third of patients at diagnosis with a further third developing metastatic disease after extirpative surgery. Heterogeneity ...
  • Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer 

    Stewart, Grant D.; Powles, Thomas; Van Neste, Christophe; Meynert, Alison; O'Mahony, Fiach; Laird, Alexander; Deforce, Dieter; Van Nieuwerburgh, Filip; Trooskens, Geert; Van Criekinge, Wim; De Meyer, Tim; Harrison, David James (2016-03-23) - Journal article
    Background: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following ...
  • Overcoming intratumoural heterogeneity for reproducible molecular risk stratification : a case study in advanced kidney cancer 

    Lubbock, Alexander L. R.; Stewart, Grant D.; O'Mahoney, Fiach C.; Laird, Alexander; Mullen, Peter; O'Donnell, Marie; Powles, Thomas; Harrison, David J.; Overton, Ian M. (2017-06-26) - Journal article
    Background: Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable ...
  • Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer 

    Stewart, Grant D; O'Mahony, Fiach; Laird, Alexander; Eory, Lel; Lubbock, Alexander; Mackay, Alan; Nanda, Jyoti; O'Donnell, Marie; Mullen, Peter; McNeill, Alan; Riddick, Antony; Berney, Daniel; Bex, Axel; Aitchison, Michael; Overton, Ian M; Harrison, David James; Powles, Thomas (2015) - Journal article
    Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple ...
  • A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma 

    Gremel, Gabriela; Djureinovic, Dijana; Niinivirta, Marjut; Laird, Alexander; Ljungqvist, Oscar; Johannesson, Henrik; Bergman, Julia; Edqvist, Perk-Henrik; Navani, Sanjay; Khan, Naila; Patil, Tushar; Sivertsson, Åsa; Uhlén, Mathias; Harrison, David James; Ullenhag, Gustav J.; Stewart, Grant D.; Pontén, Fredrik (2017-01-04) - Journal article
    Background There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). Methods Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and ...