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5-hydroxymethylcytosine profiling as an indicator of cellular state

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dc.contributor.authorLaird, Alexander
dc.contributor.authorThomson, John P.
dc.contributor.authorHarrison, David J.
dc.contributor.authorMeehan, Richard R.
dc.date.accessioned2014-08-14T14:01:01Z
dc.date.available2014-08-14T14:01:01Z
dc.date.issued2013-12
dc.identifier136160997
dc.identifier7548c8bd-b9a6-4679-abbd-ff61551a7832
dc.identifier000327470700010
dc.identifier84889646827
dc.identifier.citationLaird , A , Thomson , J P , Harrison , D J & Meehan , R R 2013 , ' 5-hydroxymethylcytosine profiling as an indicator of cellular state ' , Epigenomics , vol. 5 , no. 6 , pp. 655-669 . https://doi.org/10.2217/epi.13.69en
dc.identifier.issn1750-1911
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034229
dc.identifier.urihttps://hdl.handle.net/10023/5157
dc.descriptionA Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer. J Thomson is supported by the MARCAR project. Work in RR Meehan’s laboratory is supported by the Medical Research Council, the BBSRC and by the Innovative Medicine Initiative Joint Undertaking (IMI JU) under grant agreement number 115001 (MARCAR project).en
dc.description.abstractDNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydroxymethylcytosine and, with this, greater insight into the distribution, regulation and function of this mark, which are reviewed here. Better understanding of the associated pathways involved in regulation of, and by, 5-hydroxymethylcytosine may give promise to new therapeutic targets. We discuss evidence to support the view of 5-hydroxymethylcytosine as a unique and dynamic mark of cellular state. These 5-hydroxymethylcytosine profiles may offer optimism for the development of diagnostic, prognostic and predictive biomarkers.
dc.format.extent15
dc.format.extent3162265
dc.language.isoeng
dc.relation.ispartofEpigenomicsen
dc.subjectCanceren
dc.subjectCellular stateen
dc.subjectEpigeneticsen
dc.subjectHydroxymethylcytosineen
dc.subjectEmbryonic stem-cellsen
dc.subjectActive DNA demethylationen
dc.subjectAcetylglucosamine transferase OGTen
dc.subjectIsocitrate dehydrogenase 1en
dc.subjectAcute myeloid-leukemiaen
dc.subjectBase excision-repairen
dc.subjectMouse-liver tumorsen
dc.subjectTET proteinsen
dc.subjectThymine DNAen
dc.subjectHuman cancersen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQH426 Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0254en
dc.subject.lccQH426en
dc.title5-hydroxymethylcytosine profiling as an indicator of cellular stateen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doi10.2217/epi.13.69
dc.description.statusPeer revieweden


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