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Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast

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bellamy1994bjc183.pdf (1.156Mb)
Date
01/1994
Author
Bellamy, C O
Harrison, D J
Keywords
Adult
Aged
Breast neoplasms
Carcinoma in situ
Carcinoma, ductal, breast
Evaluation studies as topic
Female
Follow-up studies
Gene expression
Glutathione Transferase
Humans
Immunohistochemistry
Isoenzymes
Middle aged
Proto-oncogene proteins
Receptor, epidermal growth factor
Receptor, erbB-2
R Medicine
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Metadata
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Abstract
Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.
Citation
Bellamy , C O & Harrison , D J 1994 , ' Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast ' , British Journal of Cancer , vol. 69 , no. 1 , pp. 183-185 .
Publication
British Journal of Cancer
Status
Peer reviewed
ISSN
0007-0920
Type
Journal article
Rights
Copyright Macmillan Press Ltd., 1994. Full text is available as a scanned copy of the original print version from Europe PubMed Central PMC1968756
Collections
  • Medicine Research
  • University of St Andrews Research
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968756/
URI
http://hdl.handle.net/10023/6247

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