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Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest

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sheahan2007bmccancer215.pdf (748.8Kb)
Date
19/11/2007
Author
Sheahan, Sharon
Bellamy, Christopher O
Dunbar, Donald R
Harrison, David J
Prost, Sandrine
Keywords
Animals
Cell cycle
Cell proliferation
Cyclin-dependent kinase Inhibitor p16
Cyclin-dependent kinase Inhibitor p21
E2F transcription factors
Fluorescent antibody technique
Hepatocytes
Male
Mice
Mice, Knockout
Proto-oncogene proteins c-myc
Retinoblastoma protein
Signal transduction
Transforming growth factor beta
Tumor suppressor protein p53
R Medicine
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
SDG 3 - Good Health and Well-being
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Abstract
TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F activity and G1/S transition which can be inhibited in viral hepatitis. It is not known whether the impairment of pRb would alter the growth inhibitory potential of TGFbeta in disease. We asked how Rb-deficiency would affect responses to TGFbeta-induced cell cycle arrest.
Citation
Sheahan , S , Bellamy , C O , Dunbar , D R , Harrison , D J & Prost , S 2007 , ' Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest ' , BMC Cancer , vol. 7 , 215 . https://doi.org/10.1186/1471-2407-7-215
Publication
BMC Cancer
Status
Peer reviewed
DOI
https://doi.org/10.1186/1471-2407-7-215
ISSN
1471-2407
Type
Journal article
Rights
© 2007 Sheahan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Collections
  • Medicine Research
  • University of St Andrews Research
URL
http://www.biomedcentral.com/1471-2407/7/215
URI
http://hdl.handle.net/10023/6238

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