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dc.contributor.authorSheahan, Sharon
dc.contributor.authorBellamy, Christopher O
dc.contributor.authorDunbar, Donald R
dc.contributor.authorHarrison, David J
dc.contributor.authorProst, Sandrine
dc.date.accessioned2015-03-13T17:01:01Z
dc.date.available2015-03-13T17:01:01Z
dc.date.issued2007-11-19
dc.identifier.citationSheahan , S , Bellamy , C O , Dunbar , D R , Harrison , D J & Prost , S 2007 , ' Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest ' , BMC Cancer , vol. 7 , 215 . https://doi.org/10.1186/1471-2407-7-215en
dc.identifier.issn1471-2407
dc.identifier.otherPURE: 173400104
dc.identifier.otherPURE UUID: bcb80305-da07-4c01-a23a-ff451bcdfd5a
dc.identifier.otherRIS: urn:230C894206152405DBA7DF4EDABAC637
dc.identifier.otherScopus: 38349186208
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034264
dc.identifier.urihttps://hdl.handle.net/10023/6238
dc.description.abstractTGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F activity and G1/S transition which can be inhibited in viral hepatitis. It is not known whether the impairment of pRb would alter the growth inhibitory potential of TGFbeta in disease. We asked how Rb-deficiency would affect responses to TGFbeta-induced cell cycle arrest.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofBMC Canceren
dc.rights© 2007 Sheahan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAnimalsen
dc.subjectCell cycleen
dc.subjectCell proliferationen
dc.subjectCyclin-dependent kinase Inhibitor p16en
dc.subjectCyclin-dependent kinase Inhibitor p21en
dc.subjectE2F transcription factorsen
dc.subjectFluorescent antibody techniqueen
dc.subjectHepatocytesen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectMice, Knockouten
dc.subjectProto-oncogene proteins c-mycen
dc.subjectRetinoblastoma proteinen
dc.subjectSignal transductionen
dc.subjectTransforming growth factor betaen
dc.subjectTumor suppressor protein p53en
dc.subjectR Medicineen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRen
dc.subject.lccRC0254en
dc.titleDeficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arresten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1186/1471-2407-7-215
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.biomedcentral.com/1471-2407/7/215en


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