Apoptosis and DNA methylation

Meng, Huan X; Hackett, James A; Nestor, Colm; Dunican, Donncha S; Madej, Monika; Reddington, James P; Pennings, Sari; Harrison, David J; Meehan, Richard R

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Date

01/04/2011

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Abstract

Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

Citation

Meng , H X , Hackett , J A , Nestor , C , Dunican , D S , Madej , M , Reddington , J P , Pennings , S , Harrison , D J & Meehan , R R 2011 , ' Apoptosis and DNA methylation ' , Cancers , vol. 3 , no. 2 , pp. 1798-1820 . https://doi.org/10.3390/cancers3021798

Publication

Cancers

Status

Peer reviewed

DOI

https://doi.org/10.3390/cancers3021798

ISSN

2072-6694

Type

Journal article

Rights

© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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URL

http://www.mdpi.com/2072-6694/3/2/1798

URI

http://hdl.handle.net/10023/6229