Apoptosis and DNA methylation
Abstract
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Citation
Meng , H X , Hackett , J A , Nestor , C , Dunican , D S , Madej , M , Reddington , J P , Pennings , S , Harrison , D J & Meehan , R R 2011 , ' Apoptosis and DNA methylation ' Cancers , vol 3 , no. 2 , pp. 1798-1820 . DOI: 10.3390/cancers3021798
Publication
Cancers
Status
Peer reviewed
ISSN
2072-6694Type
Journal article
Rights
© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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