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dc.contributor.authorMeng, Huan X
dc.contributor.authorHackett, James A
dc.contributor.authorNestor, Colm
dc.contributor.authorDunican, Donncha S
dc.contributor.authorMadej, Monika
dc.contributor.authorReddington, James P
dc.contributor.authorPennings, Sari
dc.contributor.authorHarrison, David J
dc.contributor.authorMeehan, Richard R
dc.date.accessioned2015-03-13T15:31:15Z
dc.date.available2015-03-13T15:31:15Z
dc.date.issued2011-04-01
dc.identifier.citationMeng , H X , Hackett , J A , Nestor , C , Dunican , D S , Madej , M , Reddington , J P , Pennings , S , Harrison , D J & Meehan , R R 2011 , ' Apoptosis and DNA methylation ' , Cancers , vol. 3 , no. 2 , pp. 1798-1820 . https://doi.org/10.3390/cancers3021798en
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 173394056
dc.identifier.otherPURE UUID: b9490e34-b734-463f-b1be-1aa19958ebf2
dc.identifier.otherRIS: urn:1A0165C33872E2A9254611A2CA502BCF
dc.identifier.otherScopus: 79959734685
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034300
dc.identifier.urihttp://hdl.handle.net/10023/6229
dc.description.abstractEpigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
dc.format.extent23
dc.language.isoeng
dc.relation.ispartofCancersen
dc.rights© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en
dc.subjectEpigeneticsen
dc.subjectDnmt1en
dc.subjectApoptosisen
dc.subjectMbd4en
dc.subjectTDGen
dc.subjectDemethylationen
dc.subject5-hydroxymethylationen
dc.subjectDNA repairen
dc.subjectR Medicineen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subject.lccRen
dc.subject.lccRC0254en
dc.titleApoptosis and DNA methylationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.3390/cancers3021798
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.mdpi.com/2072-6694/3/2/1798en


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