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dc.contributor.authorMüller, Hans-Peter
dc.contributor.authorGrön, Georg
dc.contributor.authorSprengelmeyer, Reiner
dc.contributor.authorKassubek, Jan
dc.contributor.authorLudolph, Albert C.
dc.contributor.authorHobbs, Nicola
dc.contributor.authorCole, James
dc.contributor.authorRoos, Raymund A.C.
dc.contributor.authorDuerr, Alexandra
dc.contributor.authorTabrizi, Sarah J.
dc.contributor.authorLandwehrmeyer, G. Bernhard
dc.contributor.authorSüssmuth, Sigurd D.
dc.identifier.citationMüller , H-P , Grön , G , Sprengelmeyer , R , Kassubek , J , Ludolph , A C , Hobbs , N , Cole , J , Roos , R A C , Duerr , A , Tabrizi , S J , Landwehrmeyer , G B & Süssmuth , S D 2013 , ' Evaluating multicenter DTI data in Huntington's disease on site specific effects : an ex post facto approach ' , Neuroimage: Clinical , vol. 2 , pp. 161-167 .
dc.identifier.otherPURE: 61428302
dc.identifier.otherPURE UUID: 55da85a5-7157-42f6-a271-9bdac888ab0b
dc.identifier.otherRIS: urn:09F109A635C85407EF2521A5F662EB51
dc.identifier.otherScopus: 84872740490
dc.identifier.otherORCID: /0000-0002-3083-5995/work/64697279
dc.description.abstractPurpose: Assessment of the feasibility to average diffusion tensor imaging (DTI) metrics of MRI data acquired in the course of a multicenter study. Materials and methods: Sixty-one early stage Huntington's disease patients and forty healthy controls were studied using four different MR scanners at four European sites with acquisition protocols as close as possible to a given standard protocol. The potential and feasibility of averaging data acquired at different sites was evaluated quantitatively by region-of-interest (ROI) based statistical comparisons of coefficients of variation (CV) across centers, as well as by testing for significant group-by-center differences on averaged fractional anisotropy (FA) values between patients and controls. In addition, a whole-brain based statistical between-group comparison was performed using FA maps. Results: The ex post facto statistical evaluation of CV and FA-values in a priori defined ROIs showed no differences between sites above chance indicating that data were not systematically biased by center specific factors. Conclusion: Averaging FA-maps from DTI data acquired at different study sites and different MR scanner types does not appear to be systematically biased. A suitable recipe for testing on the possibility to pool multicenter DTI data is provided to permit averaging of DTI-derived metrics to differentiate patients from healthy controls at a larger scale.
dc.relation.ispartofNeuroimage: Clinicalen
dc.rights© 2013 The Authors. Published by Elsevier Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectMulticenter studyen
dc.subjectDiffusion tensor imagingen
dc.subjectFractional anisotropyen
dc.subjectHuntington's diseaseen
dc.subjectR Medicine (General)en
dc.titleEvaluating multicenter DTI data in Huntington's disease on site specific effects : an ex post facto approachen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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