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Evaluating multicenter DTI data in Huntington's disease on site specific effects : an ex post facto approach

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mueller2013neuroimageclin161.pdf (896.3Kb)
Date
2013
Author
Müller, Hans-Peter
Grön, Georg
Sprengelmeyer, Reiner
Kassubek, Jan
Ludolph, Albert C.
Hobbs, Nicola
Cole, James
Roos, Raymund A.C.
Duerr, Alexandra
Tabrizi, Sarah J.
Landwehrmeyer, G. Bernhard
Süssmuth, Sigurd D.
Keywords
Multicenter study
Diffusion tensor imaging
Fractional anisotropy
Huntington's disease
R Medicine (General)
Metadata
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Abstract
Purpose: Assessment of the feasibility to average diffusion tensor imaging (DTI) metrics of MRI data acquired in the course of a multicenter study. Materials and methods: Sixty-one early stage Huntington's disease patients and forty healthy controls were studied using four different MR scanners at four European sites with acquisition protocols as close as possible to a given standard protocol. The potential and feasibility of averaging data acquired at different sites was evaluated quantitatively by region-of-interest (ROI) based statistical comparisons of coefficients of variation (CV) across centers, as well as by testing for significant group-by-center differences on averaged fractional anisotropy (FA) values between patients and controls. In addition, a whole-brain based statistical between-group comparison was performed using FA maps. Results: The ex post facto statistical evaluation of CV and FA-values in a priori defined ROIs showed no differences between sites above chance indicating that data were not systematically biased by center specific factors. Conclusion: Averaging FA-maps from DTI data acquired at different study sites and different MR scanner types does not appear to be systematically biased. A suitable recipe for testing on the possibility to pool multicenter DTI data is provided to permit averaging of DTI-derived metrics to differentiate patients from healthy controls at a larger scale.
Citation
Müller , H-P , Grön , G , Sprengelmeyer , R , Kassubek , J , Ludolph , A C , Hobbs , N , Cole , J , Roos , R A C , Duerr , A , Tabrizi , S J , Landwehrmeyer , G B & Süssmuth , S D 2013 , ' Evaluating multicenter DTI data in Huntington's disease on site specific effects : an ex post facto approach ' , Neuroimage: Clinical , vol. 2 , pp. 161-167 . https://doi.org/10.1016/j.nicl.2012.12.005
Publication
Neuroimage: Clinical
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.nicl.2012.12.005
Type
Journal article
Rights
© 2013 The Authors. Published by Elsevier Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Collections
  • Institute of Behavioural and Neural Sciences Research
  • Psychology & Neuroscience Research
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/4789

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