St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

The Scottish Structural Proteomics Facility : targets, methods and outputs

Thumbnail
View/Open
10.1007_s10969_010_9090_y.pdf (335.3Kb)
Date
01/06/2010
Author
Oke, M
Carter, LG
Johnson, KA
Liu, H
McMahon, SA
Yan, X
Kerou, M
Weikart, ND
Kadi, N
Sheikh, MA
Schmelz, S
Dorward, M
Zawadzki, M
Cozens, C
Falconer, H
Powers, H
Overton, IM
van Niekerk, CA
Peng, X
Patel, P
Garrett, RA
Prangishvili, D
Botting, CH
Coote, PJ
Dryden, DT
Barton, GJ
Schwarz-Linek, Uli
Challis, GL
Taylor, GL
White, MF
Naismith, JH
Keywords
Computational Biology
Crystallization
Humans
Laboratories
Proteins
Proteomics
Scotland
QH426 Genetics
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.
Citation
Oke , M , Carter , LG , Johnson , KA , Liu , H , McMahon , SA , Yan , X , Kerou , M , Weikart , ND , Kadi , N , Sheikh , MA , Schmelz , S , Dorward , M , Zawadzki , M , Cozens , C , Falconer , H , Powers , H , Overton , IM , van Niekerk , CA , Peng , X , Patel , P , Garrett , RA , Prangishvili , D , Botting , CH , Coote , PJ , Dryden , DT , Barton , GJ , Schwarz-Linek , U , Challis , GL , Taylor , GL , White , MF & Naismith , JH 2010 , ' The Scottish Structural Proteomics Facility : targets, methods and outputs ' , Journal of Structural and Functional Genomics , vol. 11 , no. 2 , pp. 167-180 . https://doi.org/10.1007/s10969-010-9090-y
Publication
Journal of Structural and Functional Genomics
Status
Peer reviewed
DOI
https://doi.org/10.1007/s10969-010-9090-y
ISSN
1345-711X
Type
Journal article
Rights
© The Author(s) 2010. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Description
The SSPF was supported by grants from The Scottish Funding Council (references SSPF and SULSA), The Biotechnology and Biological Sciences Research Council (reference BB/S/B14450), European Union under framework 7 (reference Aeropath).
Collections
  • University of St Andrews Research
URL
http://www.scopus.com/inward/record.url?scp=77956754865&partnerID=8YFLogxK
http://ukpmc.ac.uk/abstract/MED/20419351
URI
http://hdl.handle.net/10023/4040

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter