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The Scottish Structural Proteomics Facility : targets, methods and outputs

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dc.contributor.authorOke, M
dc.contributor.authorCarter, LG
dc.contributor.authorJohnson, KA
dc.contributor.authorLiu, H
dc.contributor.authorMcMahon, SA
dc.contributor.authorYan, X
dc.contributor.authorKerou, M
dc.contributor.authorWeikart, ND
dc.contributor.authorKadi, N
dc.contributor.authorSheikh, MA
dc.contributor.authorSchmelz, S
dc.contributor.authorDorward, M
dc.contributor.authorZawadzki, M
dc.contributor.authorCozens, C
dc.contributor.authorFalconer, H
dc.contributor.authorPowers, H
dc.contributor.authorOverton, IM
dc.contributor.authorvan Niekerk, CA
dc.contributor.authorPeng, X
dc.contributor.authorPatel, P
dc.contributor.authorGarrett, RA
dc.contributor.authorPrangishvili, D
dc.contributor.authorBotting, CH
dc.contributor.authorCoote, PJ
dc.contributor.authorDryden, DT
dc.contributor.authorBarton, GJ
dc.contributor.authorSchwarz-Linek, Uli
dc.contributor.authorChallis, GL
dc.contributor.authorTaylor, GL
dc.contributor.authorWhite, MF
dc.contributor.authorNaismith, JH
dc.date.accessioned2013-09-09T15:01:02Z
dc.date.available2013-09-09T15:01:02Z
dc.date.issued2010-06-01
dc.identifier.citationOke , M , Carter , LG , Johnson , KA , Liu , H , McMahon , SA , Yan , X , Kerou , M , Weikart , ND , Kadi , N , Sheikh , MA , Schmelz , S , Dorward , M , Zawadzki , M , Cozens , C , Falconer , H , Powers , H , Overton , IM , van Niekerk , CA , Peng , X , Patel , P , Garrett , RA , Prangishvili , D , Botting , CH , Coote , PJ , Dryden , DT , Barton , GJ , Schwarz-Linek , U , Challis , GL , Taylor , GL , White , MF & Naismith , JH 2010 , ' The Scottish Structural Proteomics Facility : targets, methods and outputs ' , Journal of Structural and Functional Genomics , vol. 11 , no. 2 , pp. 167-180 . https://doi.org/10.1007/s10969-010-9090-yen
dc.identifier.issn1345-711X
dc.identifier.otherPURE: 3429013
dc.identifier.otherPURE UUID: eb8bffe4-5a6f-4703-aa84-95e2136080f3
dc.identifier.otherRIS: The Scottish Structural Proteomics Facility: targets, methods and outputs.
dc.identifier.otherScopus: 77956754865
dc.identifier.otherORCID: /0000-0003-1543-9342/work/47136107
dc.identifier.otherORCID: /0000-0001-5190-805X/work/40963226
dc.identifier.otherORCID: /0000-0003-0526-223X/work/40714973
dc.identifier.otherORCID: /0000-0001-9486-566X/work/60428053
dc.identifier.urihttps://hdl.handle.net/10023/4040
dc.descriptionThe SSPF was supported by grants from The Scottish Funding Council (references SSPF and SULSA), The Biotechnology and Biological Sciences Research Council (reference BB/S/B14450), European Union under framework 7 (reference Aeropath).en
dc.description.abstractThe Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.
dc.language.isoeng
dc.relation.ispartofJournal of Structural and Functional Genomicsen
dc.rights© The Author(s) 2010. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.en
dc.subjectComputational Biologyen
dc.subjectCrystallizationen
dc.subjectHumansen
dc.subjectLaboratoriesen
dc.subjectProteinsen
dc.subjectProteomicsen
dc.subjectScotlanden
dc.subjectQH426 Geneticsen
dc.subject.lccQH426en
dc.titleThe Scottish Structural Proteomics Facility : targets, methods and outputsen
dc.typeJournal articleen
dc.contributor.sponsorBBSRCen
dc.contributor.sponsorEuropean Commissionen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1007/s10969-010-9090-y
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77956754865&partnerID=8YFLogxKen
dc.identifier.urlhttp://ukpmc.ac.uk/abstract/MED/20419351en
dc.identifier.grantnumberBBS/B/14426en
dc.identifier.grantnumberHEALTH-F3-2008-223461en


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