Now showing items 1-9 of 9

    • The cyanobactin heterocyclase enzyme : A processive adenylase that operates with a defined order of reaction 

      Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Zollman, David; Smith, Kieran; Houssen, Wael E.; Zhu, Xiaofeng; Mann, Greg; Lebl, Tomas; Scharff, Richard; Shirran, Sally Lorna; Botting, Catherine Helen; Jaspers, Marcel; Schwarz-Linek, Uli; Naismith, Jim (2013-12) - Journal article
    • An internal thioester in a pathogen surface protein mediates covalent host binding 

      Walden, Miriam; Edwards, John Michael; Dziewulska, Aleksandra Malgorzata; Bergmann, Rene; Saalbach, Gerhard; Kan, Su-Yin; Miller, Ona Kealoha; Weckener, Miriam; Jackson, Rosemary J.; Shirran, Sally Lorna; Botting, Catherine Helen; Florence, Gordon John; Rohde, Manfred; Banfield, Mark J.; Schwarz-Linek, Uli (2015) - Journal article
      To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular interactions at the host-microbe interface that involve microbial ...
    • Investigation of thioester, isopeptide, and ester domain proteins from Gram-positive pathogens 

      Miller, Ona Kealoha (University of St Andrews, 2018-04-17) - Thesis
    • The proline-rich repeat and thioester domains of streptococcal fibronectin-binding proteins 

      Kan, Su-Yin (University of St Andrews, 2014-02-10) - Thesis
      Streptococcus pyogenes is an important human pathogen. One of the most prominent virulence factors produced by S. pyogenes is SfbI, a surface adhesin composed of three domains: thioester domain (TED), proline-rich repeat ...
    • The Scottish Structural Proteomics Facility : targets, methods and outputs 

      Oke, M; Carter, LG; Johnson, KA; Liu, H; McMahon, SA; Yan, X; Kerou, M; Weikart, ND; Kadi, N; Sheikh, MA; Schmelz, S; Dorward, M; Zawadzki, M; Cozens, C; Falconer, H; Powers, H; Overton, IM; van Niekerk, CA; Peng, X; Patel, P; Garrett, RA; Prangishvili, D; Botting, CH; Coote, PJ; Dryden, DT; Barton, GJ; Schwarz-Linek, Uli; Challis, GL; Taylor, GL; White, MF; Naismith, JH (2010-06-01) - Journal article
      The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures ...
    • Structural studies of bunyavirus interferon antagonist proteins 

      Barski, Michał S. (University of St Andrews, 2016-06-22) - Thesis
      Bunyaviridae is one of the biggest known viral families, and includes many viruses of clinical and economic importance. The major virulence factor of most bunyaviruses is the non-structural protein (NSs). NSs is expressed ...
    • The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster 

      Mann, Greg; Koehnke, Jesko Alexander Johannes Gunter; Bent, Andrew Frank; Graham, Rachael; Houssen, Wael; Jaspars, Marcel; Schwarz-Linek, Uli; Naismith, Jim (2014-12) - Journal article
      Patellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed ...
    • Title redacted 

      Dziewulska, Aleksandra Malgorzata (University of St Andrews, 2017-06-21) - Thesis
    • Title redacted 

      Weckener, Miriam (University of St Andrews, 2018-03-16) - Thesis