Iso-seco-tanapartholides : isolation, synthesis and biological evaluation
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The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-kappa B signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-kappa B signaling pathway. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Makiyi , E F , Frade , R F M , Lebl , T , Jaffray , E G , Cobb , S E , Harvey , A L , Slawin , A M Z , Hay , R T & Westwood , N J 2009 , ' Iso- seco -tanapartholides : isolation, synthesis and biological evaluation ' , European Journal of Organic Chemistry , vol. 2009 , no. 33 , pp. 5711-5715 . https://doi.org/10.1002/ejoc.200901016
European Journal of Organic Chemistry
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