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dc.contributor.authorMakiyi, Edward F.
dc.contributor.authorFrade, Raquel F. M.
dc.contributor.authorLebl, Tomas
dc.contributor.authorJaffray, Ellis G.
dc.contributor.authorCobb, Susan E.
dc.contributor.authorHarvey, Alan L.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorHay, Ronald T.
dc.contributor.authorWestwood, Nicholas J.
dc.date.accessioned2013-03-22T16:01:01Z
dc.date.available2013-03-22T16:01:01Z
dc.date.issued2009-11
dc.identifier.citationMakiyi , E F , Frade , R F M , Lebl , T , Jaffray , E G , Cobb , S E , Harvey , A L , Slawin , A M Z , Hay , R T & Westwood , N J 2009 , ' Iso- seco -tanapartholides : isolation, synthesis and biological evaluation ' , European Journal of Organic Chemistry , vol. 2009 , no. 33 , pp. 5711-5715 . https://doi.org/10.1002/ejoc.200901016en
dc.identifier.issn1434-193X
dc.identifier.otherPURE: 16813315
dc.identifier.otherPURE UUID: b3be03a0-b12d-46d4-84b5-a11bb3af7303
dc.identifier.otherWOS: 000272330600002
dc.identifier.otherScopus: 72849150191
dc.identifier.otherORCID: /0000-0002-0269-3221/work/48131734
dc.identifier.otherORCID: /0000-0003-0630-0138/work/56424186
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861849
dc.identifier.urihttps://hdl.handle.net/10023/3420
dc.description.abstractThe isolation, identification and total synthesis of two plant-derived inhibitors of the NF-kappa B signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-kappa B signaling pathway. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Organic Chemistryen
dc.rightsCopyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Termsen
dc.subjectNatural productsen
dc.subjectTotal synthesisen
dc.subjectTerpenoidsen
dc.subjectCleavage reactionen
dc.subjectInflammationen
dc.subjectNF-KAPPA-Ben
dc.subjectSesquiterpene lactonesen
dc.subjectNatural-productsen
dc.subjectDrug Discoveryen
dc.subjectConstituentsen
dc.subjectInhibitionen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleIso-seco-tanapartholides : isolation, synthesis and biological evaluationen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1002/ejoc.200901016
dc.description.statusPeer revieweden
dc.identifier.grantnumber516002.K5682/kken


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