Now showing items 1-6 of 6

    • Combining synthesis and biosynthesis to generate novel antibiotics 

      Abou Fayad, Antoine (University of St Andrews, 2014-12-01) - Thesis
      This thesis focuses upon pacidamycin, a member of the uridyl peptide antibiotics, a family of antibiotics which exhibit an, as yet, clinically unexploited mode of action, against MraY. The Goss group has previously ...
    • Iso-seco-tanapartholides : isolation, synthesis and biological evaluation 

      Makiyi, Edward F.; Frade, Raquel F. M.; Lebl, Tomas; Jaffray, Ellis G.; Cobb, Susan E.; Harvey, Alan L.; Slawin, Alexandra M. Z.; Hay, Ronald T.; Westwood, Nicholas J. (2009-11) - Journal article
      The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-kappa B signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient ...
    • Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis 

      Healy, Alan; Izumikawa, Miho; Slawin, Alexandra Martha Zoya; Shin-ya, Kazuo; Westwood, Nicholas James (2015-03-23) - Journal article
      Recent reports have highlighted the biological activity associated with a sub-family of the tetramic acid class of natural products. Despite the fact that members of this sub-family act as protein-protein interaction ...
    • Studies towards the total synthesis and structure elucidation of leiodolide A 

      Mould, Katy M. (University of St Andrews, 2013-11-29) - Thesis
      Leiodolide A is a unique natural product isolated from Pacific marine sponges which has provided an interesting target for total synthesis due to its complex structure and undefined stereochemistry. Although synthetic work ...
    • Studies towards the total synthesis of the pyrronazols 

      McLennan, Ross Sinclair (University of St Andrews, 2019-06-26) - Thesis
      In 2014, the pyrronazols, a family of closely related natural products were isolated from a soil dwelling myxobacteria, Nannocystis pusilla strain Ari7. The family represent a novel structural class of secondary metabolites, ...
    • The total synthesis of chamuvarinin 

      Morris, Joanne Charleen (University of St Andrews, 2013-11-29) - Thesis
      In 2004, the polyketide natural product, chamuvarinin (72) was isolated by Laurens et al. from the roots of Uvaria chamae, a member of the Annonaceae plant family. This unique tetrahydropyran containing acetogenin displayed ...