Temporal genomics in Hawaiian crickets reveals compensatory intragenomic coadaptation during adaptive evolution
Date
12/06/2024Author
Grant ID
NE/T000619/1
NE/T014806/1
NE/L011255/1
105621/Z/14/Z
Keywords
Metadata
Show full item recordAbstract
Theory predicts that compensatory genetic changes reduce negative indirect effects of selected variants during adaptive evolution, but evidence is scarce. Here, we test this in a wild population of Hawaiian crickets using temporal genomics and a high-quality chromosome-level cricket genome. In this population, a mutation, flatwing, silences males and rapidly spread due to an acoustically-orienting parasitoid. Our sampling spanned a social transition during which flatwing fixed and the population went silent. We find long-range linkage disequilibrium around the putative flatwing locus was maintained over time, and hitchhiking genes had functions related to negative flatwing-associated effects. We develop a combinatorial enrichment approach using transcriptome data to test for compensatory, intragenomic coevolution. Temporal changes in genomic selection were distributed genome-wide and functionally associated with the population’s transition to silence, particularly behavioural responses to silent environments. Our results demonstrate how ‘adaptation begets adaptation’; changes to the sociogenetic environment accompanying rapid trait evolution can generate selection provoking further, compensatory adaptation.
Citation
Zhang , X , Blaxter , M , Wood , J M D , Tracey , A , McCarthy , S , Thorpe , P , Rayner , J G , Zhang , S , Sikkink , K L , Balenger , S L & Bailey , N W 2024 , ' Temporal genomics in Hawaiian crickets reveals compensatory intragenomic coadaptation during adaptive evolution ' , Nature Communications , vol. 15 , no. 1 , 5001 . https://doi.org/10.1038/s41467-024-49344-4
Publication
Nature Communications
Status
Peer reviewed
ISSN
2041-1723Type
Journal article
Description
This study was supported with funding from the UK Natural Environment Research Council to N.W.B. (NE/T000619/1, NE/T014806/1, NE/L011255/1) and M.B. (NE/W001519/1). We are grateful for bioinformatics support from Iain Milne and the use of the UK\u2019s Crop Diversity Bioinformatics HPC, funded by the UK Biotechnology and Biological Sciences Research Council (BB/S019669/1), as well as the St Andrews Bioinformatics Unit, funded by a Wellcome Trust ISSF award (105621/Z/14/Z).Collections
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