Now showing items 1-20 of 38

  • Allometric growth in reef-building corals 

    Dornelas, Maria; Madin, Joshua S.; Baird, Andrew H.; Connolly, Sean R. (2017-03-29) - Journal article
    Predicting demographic rates is a critical part of forecasting the future of ecosystems under global change. Here, we test if growth rates can be predicted from morphological traits for a highly diverse group of colonial ...
  • An assessment of the population of cotton-top tamarins (Saguinus oedipus) and their habitat in Colombia 

    Savage, Anne; Thomas, Len; Feilen, Katie L.; Kidney, Darren; Soto, Luis H.; Pearson, Mackenzie; Medina, Felix S.; Emeris, German; Guillen, Rosamira R. (2016-12-28) - Journal article
    Numerous animals have declining populations due to habitat loss, illegal wildlife trade, and climate change. The cotton-top tamarin (Saguinus oedipus) is a Critically Endangered primate species, endemic to northwest Colombia, ...
  • Call cultures in orang-utans? 

    Wich, Serge A.; Krützen, Michael; Lameira, Adriano R.; Nater, Alexander; Arora, Natasha; Bastian, Meredith L.; Meulman, Ellen; Morrogh-Bernard, Helen C.; Utami Atmoko, S. Suci; Pamungkas, Joko; Perwitasari-Farajallah, Dyah; Hardus, Madeleine E.; van Noordwijk, Maria; van Schaik, Carel P. (2012-05-07) - Journal article
    Background: Several studies suggested great ape cultures, arguing that human cumulative culture presumably evolved from such a foundation. These focused on conspicuous behaviours, and showed rich geographic variation, which ...
  • cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases 

    Malcomson, Thomas; Kelekci, Kemal; Borrello, Maria T.; Ganesan, A.; Semina, Elena; De Kimpe, Norbert; Mangelinckx, Sven; Ramsay, Rona R. (2015-08) - Journal article
    Cyclopropylamines, inhibitors of monoamine oxidases (MAO) and lysine-specific demethylase (LSD1), provide a useful structural scaffold for the design of mechanism-based inhibitors for the therapy of depression and cancer. ...
  • Decomposition of mutational context signatures using quadratic programming methods 

    Lynch, Andy G. (2016-06-07) - Journal article
    Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...
  • Drivers of public attitudes towards small wind turbines in the UK 

    Tatchley, Cerian; Paton, Heather; Robertson, Emma; Minderman, Jeroen; Hanley, Nicholas David; Park, Kirsty (2016-03-24) - Journal article
    Small Wind Turbines (SWTs) are a growing micro-generation industry with over 870,000 installed units worldwide. No research has focussed on public attitudes towards SWTs, despite evidence the perception of such attitudes ...
  • The effect of aggregation on visibility in open water 

    Ruxton, Graeme D.; Johnsen, Sönke (2016-09-28) - Journal article
    Aggregation is a common life-history trait in open-water taxa. Qualitative understanding of how aggregation by prey influences their encounter rates with predators is critical for understanding pelagic predator-prey ...
  • Effects of age and reproductive status on individual foraging site fidelity in a long-lived marine predator 

    Votier, Stephen C.; Fayet, Annette L.; Bearhop, Stuart; Bodey, Thomas W.; Clark, Bethany L.; Grecian, James; Guilford, Tim; Hamer, Keith C.; Jeglinski, Jana W. E.; Morgan, Greg; Wakefield, Ewan; Patrick, Samantha C. (2017-07-26) - Journal article
    Individual foraging specializations, where individuals use a small component of the population niche width, are widespread in nature with important ecological and evolutionary implications. In long-lived animals, foraging ...
  • The electrophotonic silicon biosensor 

    Juan-Colás, José; Parkin, Alison; Dunn, Katherine E.; Scullion, Mark G.; Krauss, Thomas F.; Johnson, Steven D. (2016-09-14) - Journal article
    The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity ...
  • Gene expression changes in diapause or quiescent potato cyst nematode, Globodera pallida, eggs after hydration or exposure to tomato root diffusate 

    Palomares-Rius, Juan Emilio; Hedley, Pete; Cock, Peter J A; Morris, Jenny A.; Jones, John T.; Blok, Vivian C. (2016-02-04) - Journal article
    Plant-parasitic nematodes (PPN) need to be adapted to survive in the absence of a suitable host or in hostile environmental conditions. Various forms of developmental arrest including hatching inhibition and dauer stages ...
  • Genomic architecture of phenotypic divergence between two hybridizing plant species along an elevational gradient 

    Brennan, Adrian C.; Hiscock, Simon J.; Abbott, Richard John (2016-04-15) - Journal article
    Knowledge of the genetic basis of phenotypic divergence between species and how such divergence is caused and maintained is crucial to an understanding of speciation and the generation of biodiversity. The hybrid zone ...
  • Identifying the "demon whale-biter" : patterns of scarring on large whales attributed to a cookie-cutter shark Isistius sp 

    Best, Peter B.; Photopoulou, Theoni (2016-04-07) - Journal article
    The presence of crater-like wounds on cetaceans and other large marine vertebrates and invertebrates has been attributed to various organisms. We review the evidence for the identity of the biting agent responsible for ...
  • Innovation and social transmission in experimental micro-societies : exploring the scope of cumulative culture in young children 

    McGuigan, Nicola; Burdett, Emily; Burgess, Vanessa; Dean, Lewis; Lucas, Amanda; Vale, Gillian; Whiten, Andrew (2017-12-05) - Journal article
    The experimental study of cumulative culture and the innovations essential to it is a young science, with child studies so rare that the scope of cumulative cultural capacities in childhood remains largely unknown. Here ...
  • Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study 

    Ross-Adams, H.; Lamb, A. D.; Dunning, M. J.; Halim, S.; Lindberg, J.; Massie, C. M.; Egevad, L. A.; Russell, R.; Ramos-Montoya, A.; Vowler, S. L.; Sharma, N. L.; Kay, J.; Whitaker, H.; Clark, J.; Hurst, R.; Gnanapragasam, V. J.; Shah, N. C.; Warren, A. Y.; Cooper, C. S.; Lynch, A. G.; Stark, R.; Mills, I. G.; Grönberg, H.; Neal, D. E.; Shaw, Greg; Hori, Satoshi; Baridi, Ajoeb; Tran, Maxine; Wadhwa, Karan; Nelson, Adam; Patel, Keval; Thomas, Benjamin; Luxton, Hayley; Gnanpragasam, Vincent; Doble, Andrew; Kastner, Christof; Aho, Tevita; Haynes, Beverley; Partridge, Wendy; Cromwell, Elizabeth; Sangrasi, Asif; Burge, Jo; George, Anne; Stearn, Sara; Corcoran, Marie; Coret, Hansley; Basnett, Gillian; Francis, Indu; Whitington, Thomas; Yuan, Yinyin; Rueda, Oscar; Hadfield, James; Howat, Will; Miller, Jodi; Brewer, Daniel; CamCaP Study Group (2015-09) - Journal article
    Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...
  • Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo 

    Sharma, Sunil V.; Tong, Xiaoxue; Pubill-Ulldemolins, Cristina; Cartmell, Christopher; Bogosyan, Emma J. A.; Rackham, Emma J.; Marelli, Enrico; Hamed, Refaat B.; Goss, Rebecca J.M. (2017-08-09) - Journal article
    Marrying synthetic biology with synthetic chemistry provides a powerful approach toward natural product diversification, combining the best of both worlds: expediency and synthetic capability of biogenic pathways and ...
  • Long-term culture of human breast cancer specimens and their analysis using optical projection tomography 

    Leeper, Alexander D; Farrell, Joanne; Dixon, J Michael; Wedden, Sarah E; Harrison, David J; Katz, Elad (2011-07-29) - Journal article
    Breast cancer is a leading cause of mortality in the Western world. It is well established that the spread of breast cancer, first locally and later distally, is a major factor in patient prognosis. Experimental systems ...
  • Mining human prostate cancer datasets : the “camcAPP” shiny app 

    Dunning, Mark J.; Vowler, Sarah L.; Lalonde, Emilie; Ross-Adams, Helen; Boutros, Paul; Mills, Ian G.; Lynch, Andy G.; Lamb, Alastair D. (2017-03) - Journal item
  • Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice 

    Vasou, Andri; Paulus, Christina; Narloch, Janina; Gage, Zoe O.; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Nevels, Michael; Randall, Richard E.; Adamson, Catherine S. (2018-02) - Journal article
    Viral interferon (IFN) antagonists are a diverse class of viral proteins that counteract the host IFN response, which is important for controlling viral infections. Viral IFN antagonists are often multifunctional proteins ...
  • Molecular aspects of monoamine oxidase B 

    Ramsay, Rona Ruth (2016-08-01) - Journal item
    Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics ...
  • Mutational signatures of ionizing radiation in second malignancies 

    Behjati, Sam; Gundem, Gunes; Wedge, David C.; Roberts, Nicola D.; Tarpey, Patrick S.; Cooke, Susanna L.; Van Loo, Peter; Alexandrov, Ludmil B.; Ramakrishna, Manasa; Davies, Helen; Nik-Zainal, Serena; Hardy, Claire; Latimer, Calli; Raine, Keiran M.; Stebbings, Lucy; Menzies, Andy; Jones, David; Shepherd, Rebecca; Butler, Adam P.; Teague, Jon W.; Jorgensen, Mette; Khatri, Bhavisha; Pillay, Nischalan; Shlien, Adam; Futreal, P. Andrew; Badie, Christophe; McDermott, Ultan; Bova, G. Steven; Richardson, Andrea L.; Flanagan, Adrienne M.; Stratton, Michael R.; Campbell, Peter J.; Lynch, Andrew G. (2016-09-12) - Journal article
    Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...