Now showing items 1-20 of 26

  • An assessment of the population of cotton-top tamarins (Saguinus oedipus) and their habitat in Colombia 

    Savage, Anne; Thomas, Len; Feilen, Katie L.; Kidney, Darren; Soto, Luis H.; Pearson, Mackenzie; Medina, Felix S.; Emeris, German; Guillen, Rosamira R. (2016-12-28) - Journal article
    Numerous animals have declining populations due to habitat loss, illegal wildlife trade, and climate change. The cotton-top tamarin (Saguinus oedipus) is a Critically Endangered primate species, endemic to northwest Colombia, ...
  • cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases 

    Malcomson, Thomas; Kelekci, Kemal; Borrello, Maria T.; Ganesan, A.; Semina, Elena; De Kimpe, Norbert; Mangelinckx, Sven; Ramsay, Rona R. (2015-08) - Journal article
    Cyclopropylamines, inhibitors of monoamine oxidases (MAO) and lysine-specific demethylase (LSD1), provide a useful structural scaffold for the design of mechanism-based inhibitors for the therapy of depression and cancer. ...
  • Decomposition of mutational context signatures using quadratic programming methods 

    Lynch, Andy G. (2016-06-07) - Journal article
    Methods for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the ...
  • Drivers of public attitudes towards small wind turbines in the UK 

    Tatchley, Cerian; Paton, Heather; Robertson, Emma; Minderman, Jeroen; Hanley, Nicholas David; Park, Kirsty (2016-03-24) - Journal article
    Small Wind Turbines (SWTs) are a growing micro-generation industry with over 870,000 installed units worldwide. No research has focussed on public attitudes towards SWTs, despite evidence the perception of such attitudes ...
  • Effects of age and reproductive status on individual foraging site fidelity in a long-lived marine predator 

    Votier, Stephen C.; Fayet, Annette L.; Bearhop, Stuart; Bodey, Thomas W.; Clark, Bethany L.; Grecian, James; Guilford, Tim; Hamer, Keith C.; Jeglinski, Jana W. E.; Morgan, Greg; Wakefield, Ewan; Patrick, Samantha C. (2017-07-26) - Journal article
    Individual foraging specializations, where individuals use a small component of the population niche width, are widespread in nature with important ecological and evolutionary implications. In long-lived animals, foraging ...
  • The electrophotonic silicon biosensor 

    Juan-Colás, José; Parkin, Alison; Dunn, Katherine E.; Scullion, Mark G.; Krauss, Thomas F.; Johnson, Steven D. (2016-09-14) - Journal article
    The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity ...
  • Gene expression changes in diapause or quiescent potato cyst nematode, Globodera pallida, eggs after hydration or exposure to tomato root diffusate 

    Palomares-Rius, Juan Emilio; Hedley, Pete; Cock, Peter J A; Morris, Jenny A.; Jones, John T.; Blok, Vivian C. (2016-02-04) - Journal article
    Plant-parasitic nematodes (PPN) need to be adapted to survive in the absence of a suitable host or in hostile environmental conditions. Various forms of developmental arrest including hatching inhibition and dauer stages ...
  • Genomic architecture of phenotypic divergence between two hybridizing plant species along an elevational gradient 

    Brennan, Adrian C.; Hiscock, Simon J.; Abbott, Richard John (2016-04-15) - Journal article
    Knowledge of the genetic basis of phenotypic divergence between species and how such divergence is caused and maintained is crucial to an understanding of speciation and the generation of biodiversity. The hybrid zone ...
  • Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study 

    Ross-Adams, H.; Lamb, A. D.; Dunning, M. J.; Halim, S.; Lindberg, J.; Massie, C. M.; Egevad, L. A.; Russell, R.; Ramos-Montoya, A.; Vowler, S. L.; Sharma, N. L.; Kay, J.; Whitaker, H.; Clark, J.; Hurst, R.; Gnanapragasam, V. J.; Shah, N. C.; Warren, A. Y.; Cooper, C. S.; Lynch, A. G.; Stark, R.; Mills, I. G.; Grönberg, H.; Neal, D. E.; Shaw, Greg; Hori, Satoshi; Baridi, Ajoeb; Tran, Maxine; Wadhwa, Karan; Nelson, Adam; Patel, Keval; Thomas, Benjamin; Luxton, Hayley; Gnanpragasam, Vincent; Doble, Andrew; Kastner, Christof; Aho, Tevita; Haynes, Beverley; Partridge, Wendy; Cromwell, Elizabeth; Sangrasi, Asif; Burge, Jo; George, Anne; Stearn, Sara; Corcoran, Marie; Coret, Hansley; Basnett, Gillian; Francis, Indu; Whitington, Thomas; Yuan, Yinyin; Rueda, Oscar; Hadfield, James; Howat, Will; Miller, Jodi; Brewer, Daniel; CamCaP Study Group (2015-09) - Journal article
    Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups ...
  • Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo 

    Sharma, Sunil V.; Tong, Xiaoxue; Pubill-Ulldemolins, Cristina; Cartmell, Christopher; Bogosyan, Emma J. A.; Rackham, Emma J.; Marelli, Enrico; Hamed, Refaat B.; Goss, Rebecca J.M. (2017-08-09) - Journal article
    Marrying synthetic biology with synthetic chemistry provides a powerful approach toward natural product diversification, combining the best of both worlds: expediency and synthetic capability of biogenic pathways and ...
  • Long-term culture of human breast cancer specimens and their analysis using optical projection tomography 

    Leeper, Alexander D; Farrell, Joanne; Dixon, J Michael; Wedden, Sarah E; Harrison, David J; Katz, Elad (2011-07-29) - Journal article
    Breast cancer is a leading cause of mortality in the Western world. It is well established that the spread of breast cancer, first locally and later distally, is a major factor in patient prognosis. Experimental systems ...
  • Mining human prostate cancer datasets : the “camcAPP” shiny app 

    Dunning, Mark J.; Vowler, Sarah L.; Lalonde, Emilie; Ross-Adams, Helen; Boutros, Paul; Mills, Ian G.; Lynch, Andy G.; Lamb, Alastair D. (2017-03) - Journal item
  • Molecular aspects of monoamine oxidase B 

    Ramsay, Rona Ruth (2016-08-01) - Journal item
    Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics ...
  • Mutational signatures of ionizing radiation in second malignancies 

    Behjati, Sam; Gundem, Gunes; Wedge, David C.; Roberts, Nicola D.; Tarpey, Patrick S.; Cooke, Susanna L.; Van Loo, Peter; Alexandrov, Ludmil B.; Ramakrishna, Manasa; Davies, Helen; Nik-Zainal, Serena; Hardy, Claire; Latimer, Calli; Raine, Keiran M.; Stebbings, Lucy; Menzies, Andy; Jones, David; Shepherd, Rebecca; Butler, Adam P.; Teague, Jon W.; Jorgensen, Mette; Khatri, Bhavisha; Pillay, Nischalan; Shlien, Adam; Futreal, P. Andrew; Badie, Christophe; McDermott, Ultan; Bova, G. Steven; Richardson, Andrea L.; Flanagan, Adrienne M.; Stratton, Michael R.; Campbell, Peter J.; Lynch, Andrew G. (2016-09-12) - Journal article
    Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...
  • PCNA-binding proteins in the archaea : novel functionality beyond the conserved core 

    MacNeill, Stuart Andrew (2016-08) - Journal item
    Sliding clamps play an essential role in coordinating protein activity in DNA metabolism in all three domains of life. In eukaryotes and archaea the sliding clamp is PCNA (proliferating cell nuclear antigen). Across the ...
  • Perception of health from facial cues 

    Henderson, Audrey Joan; Holzleitner, Iris Jasmin; Talamas, Sean N.; Perrett, David Ian (2016-05-05) - Journal article
    Impressions of health are integral to social interactions, yet poorly understood. A review of the literature reveals multiple facial characteristics that potentially act as cues to health judgements. The cues vary in their ...
  • The psychology of primate cooperation and competition : a call for realigning research agendas 

    Schmelz, Martin; Call, Josep (2016-01-19) - Journal article
    Cooperation and competition are two key components of social life. Current research agendas investigating the psychological underpinnings of competition and cooperation in non-human primates are misaligned. The majority ...
  • A pulse of mid-Pleistocene rift volcanism in Ethiopia at the dawn of modern humans 

    Hutchison, William; Fusillo, Raffaella; Pyle, David M.; Mather, Tamsin A.; Blundy, Jon D.; Biggs, Juliet; Yirgu, Gezahegn; Cohen, Benjamin E.; Brooker, Richard A.; Barfod, Dan N.; Calvert, Andrew T. (2016-10-18) - Journal article
    The Ethiopian Rift Valley hosts the longest record of human co-existence with volcanoes on Earth, however, current understanding of the magnitude and timing of large explosive eruptions in this region is poor. Detailed ...
  • Quantum electric-dipole liquid on a triangular lattice 

    Shen, Shi-Peng; Wu, Jia-Chuan; Song, Jun-Da; Sun, Xue-Feng; Yang, Yi-Feng; Chai, Yi-Sheng; Shang, Da-Shan; Wang, Shou-Guo; Scott, James F.; Sun, Young (2016-02-04) - Journal article
    Geometric frustration and quantum fluctuations may prohibit the formation of long-range ordering even at the lowest temperature, and therefore liquid-like ground states could be expected. A good example is the quantum spin ...
  • Spatial models of abundance and habitat preferences of Commerson’s and Peale’s dolphin in southern Patagonian waters 

    Dellabianca, Natalia A.; Pierce, Graham J.; Rey, Andrea Raya; Scioscia, Gabriela; Miller, David L.; Torres, Mónica A.; Viola, M. Natalia Paso; Goodall, R. Natalie P; Schiavini, Adrián C M (2016-10-26) - Journal article
    Commerson’s dolphins (Cephalorhynchus c. commersonii) and Peale’s dolphins (Lagenorhynchus australis) are two of the most common species of cetaceans in the coastal waters of southwest South Atlantic Ocean. Both species ...