Multi-layered genome defences in bacteria
Abstract
Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.
Citation
Agapov , A , Baker , K S , Bedekar , P , Bhatia , R P , Blower , T R , Brockhurst , M A , Brown , C , Chong , C E , Fothergill , J L , Graham , S , Hall , J PJ , Maestri , A , McQuarrie , S , Olina , A , Pagliara , S , Recker , M , Richmond , A , Shaw , S J , Szczelkun , M D , Taylor , T B , van Houte , S , Went , S C , Westra , E R , White , M F & Wright , R 2024 , ' Multi-layered genome defences in bacteria ' , Current Opinion in Microbiology , vol. 78 , 102436 . https://doi.org/10.1016/j.mib.2024.102436
Publication
Current Opinion in Microbiology
Status
Peer reviewed
ISSN
1369-5274Type
Journal item
Description
This work was supported by a grant from the Biotechnology and Biological Sciences Research Council sLoLa BB/X003051/1 , awarded to KB, TRB, MB, JF, JH, SP, MR, MDS, TBT, SVH, ERW and MFW. JH is supported by an MRC Career Development Award ( MR/W02666X/1 ). AA is supported by UK Research and Innovation under the UK government’s Horizon Europe funding guarantee ( EP/Y020308/1 ).Collections
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