Now showing items 1-10 of 10

    • Factors underlying Ebola virus infection among health workers, Kenema, Sierra Leone, 2014-2015 

      Senga, Mikiko; Pringle, Kimberly; Ramsay, Andrew; Brett-Major, David M.; Fowler, Robert A.; French, Issa; Vandi, Mohamed; Sellu, Josephine; Pratt, Christian; Saidu, Josephine; Shindo, Nahoko; Bausch, Daniel G.; Sierra Leone Kenema District Task Force and Kenema General Hospital (2016-08-15) - Journal article
      Background. Ebola virus disease (EVD) in health workers (HWs) has been a major challenge during the 2014-2015 outbreak. We examined factors associated with Ebola virus exposure and mortality in HWs in Kenema District, ...
    • Genetic determinants of the pharmacokinetic variability of rifampin in Malawian adults with pulmonary tuberculosis 

      Sloan, Derek J.; McCallum, Andrew D.; Schipani, Alessandro; Egan, Deirdre; Mwandumba, Henry C.; Ward, Steve A.; Waterhouse, David; Banda, Gertrude; Allain, Theresa J.; Owen, Andrew; Khoo, Saye H.; Davies, Geraint R. (2017-07-01) - Journal article
      Variable exposure to antituberculosis (TB) drugs, partially driven by genetic factors, may be associated with poor clinical outcomes. Previous studies have suggested an influence of the SLCO1B1 locus on the plasma area ...
    • Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis 

      Mzinza, David T.; Sloan, Derek James; Jambo, Kondwani C.; Shani, Doris; Kamdolozi, Mercy; Wilkinson, Katalin A.; Wilkinson, Robert J.; Davies, Geraint R.; Heyderman, Robert S.; Mwandumba, Henry C. (2015-07-01) - Journal article
      In HIV-uninfected adults with pulmonary tuberculosis (TB), anti-TB treatment is associated with changes in Mycobacterium tuberculosis (Mtb)-specific immune responses, which correlate with sputum bacillary load. It is unclear ...
    • Late presentation with HIV in Africa : phenotypes, risk, and risk stratification in the REALITY trial 

      Siika, Abraham; McCabe, Leanne; Bwakura-Dangarembizi, Mutsa; Kityo, Cissy; Mallewa, Jane; Berkley, Jay; Maitland, Kath; Griffiths, Anna; Baleeta, Keith; Mudzingwa, Shepherd; Abach, James; Nathoo, Kusum; Thomason, Margaret J.; Prendergast, Andrew J.; Walker, Ann Sarah; Gibb, Diana M.; Mugyenyi, P.; Kityo, C.; Musiime, V.; Wavamunno, P.; Nambi, E.; Ocitti, P.; Ndigendawani, M.; Kemigisa, M.; Acen, J.; Olebo, D.; Mpamize, G.; Amone, A.; Okweny, D.; Mbonye, A.; Nambaziira, F.; Rweyora, A.; Kangah, M.; Kabaswahili, V.; Abach, J.; Abongomera, G.; Omongin, J.; Aciro, I.; Philliam, A.; Arach, B.; Ocung, E.; Amone, G.; Miles, P.; Adong, C.; Tumsuiime, C.; Kidega, P.; Otto, B.; Apio, F.; Baleeta, K.; O'Hare, B. (2018-04-01) - Journal article
      Background. Severely immunocompromised human immunodefciency virus (HIV)-infected individuals have high mortality shortly afer starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late ...
    • Management of multidrug-resistant TB : novel treatments and their expansion to low resource settings 

      Sloan, Derek James; Lewis, Joseph M. (2016-03) - Journal item
      Despite overall progress in global TB control, the rising burden ofmultidrug-resistant TB (MDR-TB) threatens to undermine efforts to end theworldwide epidemic. Of the 27 countries classified as high burden for MDR-TB, 17 ...
    • Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice 

      Vasou, Andri; Paulus, Christina; Narloch, Janina; Gage, Zoe O.; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Nevels, Michael; Randall, Richard E.; Adamson, Catherine S. (2018-02) - Journal article
      Viral interferon (IFN) antagonists are a diverse class of viral proteins that counteract the host IFN response, which is important for controlling viral infections. Viral IFN antagonists are often multifunctional proteins ...
    • Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis 

      Sloan, Derek James; Mwandumba, Henry C.; Garton, Natalie J.; Khoo, Saye H.; Butterworth, Anthony E.; Allain, Theresa J.; Heyderman, Robert S.; Corbett, Elizabeth L.; Barer, Mike R.; Davies, Geraint R. (2015-07-01) - Journal article
      Background. Antibiotic-tolerant bacterial persistence prevents treatment shortening in drug-susceptible tuberculosis, and accumulation of intracellular lipid bodies has been proposed to identify a persister phenotype of ...
    • Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments 

      Barski, Michal; Brennan, Benjamin; Miller, Ona K.; Potter, Jane A.; Vijayakrishnan, Swetha; Bhella, David; Naismith, James H.; Elliott, Richard M.; Schwarz-Linek, Ulrich (2017-09-15) - Journal article
      Rift Valley fever phlebovirus (RVFV) is a clinically and economically important pathogen increasingly likely to cause widespread epidemics. RVFV virulence depends on the interferon antagonist non-structural protein (NSs), ...
    • TonB-dependent receptor repertoire of pseudomonas aeruginosa for uptake of siderophore-drug conjugates 

      Luscher, Alexandre; Moynie, Lucile; Auguste, Pamela Saint; Bumann, Dirk; Mazza, Lena; Pletzer, Daniel; Naismith, James H.; Köhlera, Thilo (2018-06) - Journal article
      The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates ...
    • Vitamin D deficiency in Malawian adults with pulmonary tuberculosis : risk factors and treatment outcomes 

      Sloan, Derek James; Mwandumba, H. C.; Kamdolozi, M.; Shani, D.; Chisale, B.; Dutton, J.; Khoo, S. H.; Allain, T. J.; Davies, G. R. (2015-08-01) - Journal article
      SETTING: Vitamin D deficiency is common in African adults with tuberculosis (TB), and may be exacerbated by the metabolic effects of anti-tuberculosis drugs and antiretroviral therapy (ART). It is unclear whether vitamin ...