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Multi-layered genome defences in bacteria

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dc.contributor.authorAgapov, Aleksei
dc.contributor.authorBaker, Kate S.
dc.contributor.authorBedekar, Paritosh
dc.contributor.authorBhatia, Rama P.
dc.contributor.authorBlower, Tim R.
dc.contributor.authorBrockhurst, Michael A.
dc.contributor.authorBrown, Cooper
dc.contributor.authorChong, Charlotte E.
dc.contributor.authorFothergill, Joanne L.
dc.contributor.authorGraham, Shirley
dc.contributor.authorHall, James PJ
dc.contributor.authorMaestri, Alice
dc.contributor.authorMcQuarrie, Stuart
dc.contributor.authorOlina, Anna
dc.contributor.authorPagliara, Stefano
dc.contributor.authorRecker, Mario
dc.contributor.authorRichmond, Anna
dc.contributor.authorShaw, Steven J.
dc.contributor.authorSzczelkun, Mark D.
dc.contributor.authorTaylor, Tiffany B.
dc.contributor.authorvan Houte, Stineke
dc.contributor.authorWent, Sam C.
dc.contributor.authorWestra, Edze R.
dc.contributor.authorWhite, Malcolm F.
dc.contributor.authorWright, Rosanna
dc.date.accessioned2024-05-30T10:30:13Z
dc.date.available2024-05-30T10:30:13Z
dc.date.issued2024-04
dc.identifier302155980
dc.identifiera8de3f85-df72-4d40-b245-9eb1e2835fbc
dc.identifier85185407446
dc.identifier38368839
dc.identifier.citationAgapov , A , Baker , K S , Bedekar , P , Bhatia , R P , Blower , T R , Brockhurst , M A , Brown , C , Chong , C E , Fothergill , J L , Graham , S , Hall , J PJ , Maestri , A , McQuarrie , S , Olina , A , Pagliara , S , Recker , M , Richmond , A , Shaw , S J , Szczelkun , M D , Taylor , T B , van Houte , S , Went , S C , Westra , E R , White , M F & Wright , R 2024 , ' Multi-layered genome defences in bacteria ' , Current Opinion in Microbiology , vol. 78 , 102436 . https://doi.org/10.1016/j.mib.2024.102436en
dc.identifier.issn1369-5274
dc.identifier.urihttps://hdl.handle.net/10023/29949
dc.descriptionThis work was supported by a grant from the Biotechnology and Biological Sciences Research Council sLoLa BB/X003051/1 , awarded to KB, TRB, MB, JF, JH, SP, MR, MDS, TBT, SVH, ERW and MFW. JH is supported by an MRC Career Development Award ( MR/W02666X/1 ). AA is supported by UK Research and Innovation under the UK government’s Horizon Europe funding guarantee ( EP/Y020308/1 ).en
dc.description.abstractBacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.
dc.format.extent10
dc.format.extent3327863
dc.language.isoeng
dc.relation.ispartofCurrent Opinion in Microbiologyen
dc.subjectMicrobiologyen
dc.subjectMicrobiology (medical)en
dc.subjectInfectious Diseasesen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectTBCen
dc.titleMulti-layered genome defences in bacteriaen
dc.typeJournal itemen
dc.contributor.sponsorBBSRCen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. St Andrews Bioinformatics Uniten
dc.identifier.doihttps://doi.org/10.1016/j.mib.2024.102436
dc.description.statusPeer revieweden
dc.identifier.grantnumberBB/X003051/1en


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