Now showing items 1-5 of 5

    • Evaluation of Xpert MTB/RIF for detection of tuberculosis from blood samples of HIV-infected adults confirms Mycobacterium tuberculosis bacteremia as an indicator of poor prognosis 

      Feasey, Nicholas A.; Banada, Padmapriya P.; Howson, William; Sloan, Derek J.; Mdolo, Aaron; Boehme, Catharina; Chipungu, Geoffrey A.; Allain, Theresa J.; Heyderman, Robert S.; Corbett, Elizabeth L.; Alland, David (2013-05-15) - Journal article
      Tuberculosis (TB) remains a leading cause of death among HIV-infected adults, in part because of delayed diagnosis and therefore delayed initiation of treatment. Recently, the Gene-Xpert platform, a rapid, PCR-based ...
    • Factors underlying Ebola virus infection among health workers, Kenema, Sierra Leone, 2014-2015 

      Senga, Mikiko; Pringle, Kimberly; Ramsay, Andrew; Brett-Major, David M.; Fowler, Robert A.; French, Issa; Vandi, Mohamed; Sellu, Josephine; Pratt, Christian; Saidu, Josephine; Shindo, Nahoko; Bausch, Daniel G.; Sierra Leone Kenema District Task Force and Kenema General Hospital (2016-08-15) - Journal article
      Background. Ebola virus disease (EVD) in health workers (HWs) has been a major challenge during the 2014-2015 outbreak. We examined factors associated with Ebola virus exposure and mortality in HWs in Kenema District, ...
    • Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis 

      Mzinza, David T.; Sloan, Derek James; Jambo, Kondwani C.; Shani, Doris; Kamdolozi, Mercy; Wilkinson, Katalin A.; Wilkinson, Robert J.; Davies, Geraint R.; Heyderman, Robert S.; Mwandumba, Henry C. (2015-07-01) - Journal article
      In HIV-uninfected adults with pulmonary tuberculosis (TB), anti-TB treatment is associated with changes in Mycobacterium tuberculosis (Mtb)-specific immune responses, which correlate with sputum bacillary load. It is unclear ...
    • Late presentation with HIV in Africa : phenotypes, risk, and risk stratification in the REALITY trial 

      Siika, Abraham; McCabe, Leanne; Bwakura-Dangarembizi, Mutsa; Kityo, Cissy; Mallewa, Jane; Berkley, Jay; Maitland, Kath; Griffiths, Anna; Baleeta, Keith; Mudzingwa, Shepherd; Abach, James; Nathoo, Kusum; Thomason, Margaret J.; Prendergast, Andrew J.; Walker, Ann Sarah; Gibb, Diana M.; Mugyenyi, P.; Kityo, C.; Musiime, V.; Wavamunno, P.; Nambi, E.; Ocitti, P.; Ndigendawani, M.; Kemigisa, M.; Acen, J.; Olebo, D.; Mpamize, G.; Amone, A.; Okweny, D.; Mbonye, A.; Nambaziira, F.; Rweyora, A.; Kangah, M.; Kabaswahili, V.; Abach, J.; Abongomera, G.; Omongin, J.; Aciro, I.; Philliam, A.; Arach, B.; Ocung, E.; Amone, G.; Miles, P.; Adong, C.; Tumsuiime, C.; Kidega, P.; Otto, B.; Apio, F.; Baleeta, K.; O'Hare, B. (2018-04-01) - Journal article
      Background. Severely immunocompromised human immunodefciency virus (HIV)-infected individuals have high mortality shortly afer starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late ...
    • Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis 

      Sloan, Derek James; Mwandumba, Henry C.; Garton, Natalie J.; Khoo, Saye H.; Butterworth, Anthony E.; Allain, Theresa J.; Heyderman, Robert S.; Corbett, Elizabeth L.; Barer, Mike R.; Davies, Geraint R. (2015-07-01) - Journal article
      Background. Antibiotic-tolerant bacterial persistence prevents treatment shortening in drug-susceptible tuberculosis, and accumulation of intracellular lipid bodies has been proposed to identify a persister phenotype of ...