The electrophotonic silicon biosensor
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The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. Here we introduce an electrochemical silicon photonic sensor capable of highly sensitive and multiparameter profiling of biomarkers. Our electrophotonic technology consists of microring resonators optimally n-doped to support high Q resonances alongside electrochemical processes in situ. The inclusion of electrochemical control enables site-selective immobilization of different biomolecules on individual microrings within a sensor array. The combination of photonic and electrochemical characterization also provides additional quantitative information and unique insight into chemical reactivity that is unavailable with photonic detection alone. By exploiting both the photonic and the electrical properties of silicon, the sensor opens new modalities for Sensing on the microscale.
Juan-Colás , J , Parkin , A , Dunn , K E , Scullion , M G , Krauss , T F & Johnson , S D 2016 , ' The electrophotonic silicon biosensor ' Nature Communications , vol 7 , 12769 . DOI: 10.1038/ncomms12769
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DescriptionJ.J.-C. was supported by a PhD studentship funded by the Departments of Physics and Electronics of the University of York. K.E.D. and S.D.J. acknowledge the University of York for the award of an Institutional Equipment Grant and financial support from the EPSRC Platform Grant EP/K040820/1. M.G.S. and T.F.K. thank the EPSRC Programme Grant ‘Structured Light’ EP/J01771X/1 for financial support. A.P., S.D.J. and T.F.K. acknowledge the support of the Biological Physical Sciences Institute at the University of York.
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