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dc.contributor.authorJuan-Colás, José
dc.contributor.authorParkin, Alison
dc.contributor.authorDunn, Katherine E.
dc.contributor.authorScullion, Mark G.
dc.contributor.authorKrauss, Thomas F.
dc.contributor.authorJohnson, Steven D.
dc.date.accessioned2017-10-04T16:30:28Z
dc.date.available2017-10-04T16:30:28Z
dc.date.issued2016-09-14
dc.identifier.citationJuan-Colás , J , Parkin , A , Dunn , K E , Scullion , M G , Krauss , T F & Johnson , S D 2016 , ' The electrophotonic silicon biosensor ' Nature Communications , vol. 7 , 12769 . DOI: 10.1038/ncomms12769en
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 251276807
dc.identifier.otherPURE UUID: dfd806ca-ff2c-4c00-9701-d3d4af98e913
dc.identifier.otherScopus: 84987841005
dc.identifier.urihttp://hdl.handle.net/10023/11801
dc.identifier.urihttps://www.nature.com/articles/ncomms12769#supplementary-informationen
dc.descriptionJ.J.-C. was supported by a PhD studentship funded by the Departments of Physics and Electronics of the University of York. K.E.D. and S.D.J. acknowledge the University of York for the award of an Institutional Equipment Grant and financial support from the EPSRC Platform Grant EP/K040820/1. M.G.S. and T.F.K. thank the EPSRC Programme Grant ‘Structured Light’ EP/J01771X/1 for financial support. A.P., S.D.J. and T.F.K. acknowledge the support of the Biological Physical Sciences Institute at the University of York.en
dc.description.abstractThe emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. Here we introduce an electrochemical silicon photonic sensor capable of highly sensitive and multiparameter profiling of biomarkers. Our electrophotonic technology consists of microring resonators optimally n-doped to support high Q resonances alongside electrochemical processes in situ. The inclusion of electrochemical control enables site-selective immobilization of different biomolecules on individual microrings within a sensor array. The combination of photonic and electrochemical characterization also provides additional quantitative information and unique insight into chemical reactivity that is unavailable with photonic detection alone. By exploiting both the photonic and the electrical properties of silicon, the sensor opens new modalities for Sensing on the microscale.en
dc.format.extent7en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectQC Physicsen
dc.subjectQD Chemistryen
dc.subjectChemistry(all)en
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectPhysics and Astronomy(all)en
dc.subjectDASen
dc.subject.lccQCen
dc.subject.lccQDen
dc.titleThe electrophotonic silicon biosensoren
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1038/ncomms12769
dc.description.statusPeer revieweden


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