A validated normative model for human uterine volume from birth to age 40 years
Abstract
Transabdominal pelvic ultrasound and/or pelvic Magnetic Resonance Imaging are safe, accurate and non - invasive means of determining the size and configuration of the internal female genitalia. The assessment of uterine size and volume is helpful in the assessment of many conditions including disorders of sex development, precocious or delayed puberty, infertility and menstrual disorders. Using our own data from the assessment of MRI scans in healthy young females and data extracted from four studies that assessed uterine volume using transabdominal ultrasound in healthy females we have derived and validated a normative model of uterine volume from birth to age 40 years. This shows that uterine volume increases across childhood, with a faster increase in adolescence reflecting the influence of puberty, followed by a slow but progressive rise during adult life. The model suggests that around 84% of the variation in uterine volumes in the healthy population up to age 40 is due to age alone . The derivation of a validated normative model for uterine volume from birth to age 40 years has important clinical applications by providing age-related reference values for uterine volume.
Citation
Kelsey , T W , Ginbey , E , Chowdhury , M M , Bath , L E , Anderson , R A & Wallace , W H B 2016 , ' A validated normative model for human uterine volume from birth to age 40 years ' , PLoS One , vol. 11 , no. 6 , e0157375 . https://doi.org/10.1371/journal.pone.0157375 , https://doi.org/10.1371/journal.pone.0157375
Publication
PLoS One
Status
Peer reviewed
ISSN
1932-6203Type
Journal article
Collections
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