Selective NaOH-catalysed hydration of aromatic nitriles to amides
Abstract
The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.
Citation
Schmid , T , Gomez Herrera , A , Songis , O , Sneddon , D , Révolte , A , Nahra , F & Cazin , C S J 2015 , ' Selective NaOH-catalysed hydration of aromatic nitriles to amides ' , Catalysis Science & Technology , vol. 5 , no. 5 , pp. 2865-2868 . https://doi.org/10.1039/C5CY00313J
Publication
Catalysis Science & Technology
Status
Peer reviewed
ISSN
2044-4753Type
Journal article
Rights
Copyright 2015 the Authors. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1039/C5CY00313J.
Description
The authors gratefully acknowledge the Royal Society (University Research Fellowship to CSJC)Collections
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.