Selective NaOH-catalysed hydration of aromatic nitriles to amides
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The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.
Schmid , T , Gomez Herrera , A , Songis , O , Sneddon , D , Révolte , A , Nahra , F & Cazin , C S J 2015 , ' Selective NaOH-catalysed hydration of aromatic nitriles to amides ' Catalysis Science & Technology , vol 5 , no. 5 , pp. 2865-2868 . DOI: 10.1039/C5CY00313J
Catalysis Science & Technology
Copyright 2015 the Authors. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1039/C5CY00313J.
The authors gratefully acknowledge the Royal Society (University Research Fellowship to CSJC)
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