Brain swelling and death in children with cerebral malaria

Seydel, Karl B; Kampondeni, Samuel D; Valim, Clarissa; Potchen, Michael J; Milner, Danny A; Muwalo, Francis W; Birbeck, Gretchen L; Bradley, William G; Fox, Lindsay L; Glover, Simon J; Hammond, Colleen A; Heyderman, Robert S; Chilingulo, Cowles A; Molyneux, Malcolm E; Taylor, Terrie E

View/Open

Glover_BrainSwelling_NEJoM_FinalPubVersion.pdf (895.0Kb)

Date

19/03/2015

Altmetrics Handle Statistics

Altmetrics DOI Statistics

Abstract

Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.

Citation

Seydel , K B , Kampondeni , S D , Valim , C , Potchen , M J , Milner , D A , Muwalo , F W , Birbeck , G L , Bradley , W G , Fox , L L , Glover , S J , Hammond , C A , Heyderman , R S , Chilingulo , C A , Molyneux , M E & Taylor , T E 2015 , ' Brain swelling and death in children with cerebral malaria ' , New England Journal of Medicine , vol. 372 , no. 12 , pp. 1126-37 . https://doi.org/10.1056/NEJMoa1400116

Publication

New England Journal of Medicine

Status

Peer reviewed

DOI

https://doi.org/10.1056/NEJMoa1400116

ISSN

0028-4793

Type

Journal article

Rights

© 2015 Massachusetts Medical Society. All rights reserved. This work is made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at https://dx.doi.org/10.1056/NEJMoa1400116

Description

Supported by a grant (5R01AI034969) from the National Institutes of Health and by a Strategic Award for the Malawi–Liverpool–Wellcome Clinical Research Programme from the Wellcome Trust U.K. General Electric Healthcare donated the Signa 0.35-T magnetic resonance imager (MRI) used in this work, and the Michigan State University College of Osteopathic Medicine sponsored the construction of the building that houses the MRI in Malawi.

Collections

University of St Andrews Research

URI

http://hdl.handle.net/10023/8303