Now showing items 1-6 of 6

  • Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections 

    Cox-Singh, Janet; Singh, Balbir; Daneshvar, Cyrus; Planche, Timothy; Parker-Williams, John; Krishna, Sanjeev; Cox Singh, Janet (2011-06-08) - Journal article
    Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection. Therefore ...
  • Brain swelling and death in children with cerebral malaria 

    Seydel, Karl B; Kampondeni, Samuel D; Valim, Clarissa; Potchen, Michael J; Milner, Danny A; Muwalo, Francis W; Birbeck, Gretchen L; Bradley, William G; Fox, Lindsay L; Glover, Simon J; Hammond, Colleen A; Heyderman, Robert S; Chilingulo, Cowles A; Molyneux, Malcolm E; Taylor, Terrie E (2015-03-19) - Journal article
    Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological ...
  • An investigation into mannose activation and its impact on glycosylphosphatidylinositol biosynthesis in Plasmodium falciparum 

    Williams, Chris L. (University of St Andrews, 2015-06-24) - Thesis
    Malaria caused by the protozan parasite Plasmodium is one of the most serious infectious diseases in the developing world. It is estimated that malaria causes an annual mortality rate of ~627,000. New drugs are urgently ...
  • Plasmodium knowlesi – an emerging pathogen 

    Ahmed, M.A.; Cox Singh, Janet (2015-04) - Journal item
    Ten years have passed since the publication of a large focus of Plasmodium knowlesi infections in the human population. The discovery was made during molecular investigation of atypical P. malariae cases in the Kapit Health ...
  • Sugar activation and glycosylation in Plasmodium 

    Cova, Marta; Rodrigues, João A.; Smith, Terry K; Izquierdo, Luis (2015-10-31) - Journal article
    Glycoconjugates are important mediators of host-pathogen interactions and are usually very abundant in the surface of many protozoan parasites. However, in the particular case of Plasmodium species, previous works show ...
  • Susceptibility of human plasmodium knowlesi infections to anti-malarials 

    Fatih, Farrah A.; Staines, Henry M.; Siner, Angela; Ahmed, Mohammed Atique; Woon, Lu Chan; Pasini, Erica M.; Kocken, Clemens H. M.; Singh, Balbir; Cox Singh, Janet; Krishna, Sanjeev (2013-11-19) - Journal article
    Background: Evidence suggests that Plasmodium knowlesi malaria in Sarawak, Malaysian Borneo remains zoonotic, meaning anti-malarial drug resistance is unlikely to have developed in the absence of drug selection pressure. ...