Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis
MetadataShow full item record
Current clinical practice in cancer stratifies patients based on tumour histology to determine prognosis. Molecular profiling has been hailed as the path towards personalised care, but molecular data are still typically analysed independently of known clinical information. Conventional clinical and histopathological data, if used, are added only to improve a molecular prediction, placing a high burden upon molecular data to be informative in isolation. Here, we develop a novel Monte Carlo analysis to evaluate the usefulness of data assemblages. We applied our analysis to varying assemblages of clinical data and molecular data in an ovarian cancer dataset, evaluating their ability to discriminate one-year progression-free survival (PFS) and three-year overall survival (OS). We found that Cox proportional hazard regression models based on both data types together provided greater discriminative ability than either alone. In particular, we show that proteomics data assemblages that alone were uninformative (p = 0.245 for PFS, p = 0.526 for OS) became informative when combined with clinical information (p = 0.022 for PFS, p = 0.048 for OS). Thus, concurrent analysis of clinical and molecular data enables exploitation of prognosis-relevant information that may not be accessible from independent analysis of these data types.
Verleyen , W , Langdon , S P , Faratian , D , Harrison , D J & Smith , V A 2015 , ' Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis ' Scientific Reports , vol. 5 , 15563 . DOI: 10.1038/srep15563
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
DescriptionWV is a SULSA Systems Biology Prize PhD Student; VAS is supported by the BBSRC Research Council [grant number BB/F001398/1] and Medical Research Scotland [grant number FRG353]. DJH is supported by CASyM Concerted Action [grant number EU HEALTH-F4-2012-305033] and the Chief Scientist Office of Scotland.
- Centre for Biological Diversity (CBD) Research
- University of St Andrews Research
- Biology Research
- Medicine Research
- Centre for Research into Ecological & Environmental Modelling (CREEM) Research
- Institute of Behavioural and Neural Sciences Research
- Scottish Oceans Institute Research
- Centre for Higher Education Research (CHER) Research
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.