Now showing items 1-20 of 25

  • Antitumour activity of the novel flavonoid oncamex in preclinical breast cancer models 

    Martínez-Pérez, Carlos; Ward, Carol; Turnbull, Arran K; Mullen, Peter; Cook, Graham; Meehan, James; Jarman, Edward J; Thomson, Patrick I T; Campbell, Colin J; McPhail, Donald; Harrison, David James; Langdon, Simon P (2016-04-13) - Journal article
    Background: The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved cell uptake and ...
  • Chemical analysis of multicellular tumour spheroids 

    Jamieson, L.E.; Harrison, David James; Campbell, C.J. (2015-06-21) - Journal article
    Conventional two dimensional (2D) monolayer cell culture has been considered the ‘gold standard’ technique for in vitro cellular experiments. However, the need for a model that better mimics the three dimensional (3D) ...
  • Could molecular pathology testing in lung cancer be more cost effective? 

    Walsh, Kathy; Kheng, Yuan; Oniscu, Anca; Harrison, David James; Wallace, William (2016-10) - Journal article
    Aims: EGFR and ALK analysis is routinely undertaken prior to targeted treatment of non-squamous non-small cell lung carcinoma (NSCLC). Increasingly limited resources require molecular pathology services to be cost effective ...
  • Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer 

    Stewart, Grant D.; Powles, Thomas; Van Neste, Christophe; Meynert, Alison; O'Mahony, Fiach; Laird, Alexander; Deforce, Dieter; Van Nieuwerburgh, Filip; Trooskens, Geert; Van Criekinge, Wim; De Meyer, Tim; Harrison, David James (2016-03-23) - Journal article
    Background: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following ...
  • Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models 

    Koussounadis, Antonis; Langdon, Simon; Um, In Hwa; Kay, Charlene; Francis, Kyle; Harrison, David James; Smith, V Anne (2016-03-10) - Journal article
    Background: The dynamic changes that occur in protein expression after treatment of a cancer in vivo are poorly described. In this study we measure the effect of chemotherapy over time on the expression of a panel of ...
  • Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models 

    Ward, Carol; Meehan, James; Mullen, Peter; Supuran, Claudiu; Dixon, J. Michael; Thomas, Jeremy S.; Winum, Jean-Yves; Lambin, Philippe; Dubois, Ludwig; Pavathaneni, Nanda-Kumar; Jarman, Edward J.; Renshaw, Lorna; Um, In Hwa; Kay, Charlene; Harrison, David James; Kunkler, Ian H.; Langdon, Simon P. (2015) - Journal article
    Triple negative, resistant or metastatic disease are major factors in breast cancer mortality, warranting novel approaches. Carbonic anhydrase IX (CAIX) is implicated in survival, migration and invasion of breast cancer ...
  • A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk 

    Katz, E.; Dubois-Marshall, S.; Sims, A. H.; Faratian, D.; Li, J.; Smith, E. S.; Quinn, J. A.; Edward, M.; Meehan, R. R.; Evans, E. E.; Langdon, S. P.; Harrison, David James (2010-07-27) - Journal article
    BACKGROUND: C35 is a 12 kDa membrane-anchored protein endogenously over-expressed in many invasive breast cancers. C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. The function of over-expressed C35 ...
  • Human tissue in systems medicine 

    Caie, Peter David; Schuur, Klaas; Oniscu, Anca; Mullen, Peter; Reynolds, Paul Andrew; Harrison, David James (2013-12) - Journal item
    Histopathology, the examination of an architecturally artefactual, two dimensional, static image remains a potent tool allowing diagnosis and empirical expectation of prognosis. Considerable optimism exists that the advent ...
  • Human urinary exosomes in bladder cancer patients : properties, concentrations and possible clinical application 

    Riches, Andrew Clive; Powis, Simon John; Mullen, Peter; Harrison, David James; Hacker, Christian; Lucocq, John Milton; Bowness, James Simeon; Chapman, Alex; Cameron, Ruth; McLornan, Liz; Chinn, David John; Leung, Steve (2015-12-11) - Journal article
    OBJECTIVE: High grade bladder cancer is extremely aggressive. Early detection is thus an important challenge. De- velopment of non-invasive diagnostic tools particularly using urine samples could be of importance in the ...
  • Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells 

    Meehan, James; Ward, Carol; Turnbull, Arran; Bukowski-Wills, Jimi; Finch, Andrew; Jarman, Edward J.; Xintaropoulou, Chrysi; Martinez-Perez, Carlos; Gray, Mark; Pearson, Matthew; Mullen, Peter; Supuran, Claudia T.; Carta, Fabrizio; Harrison, David James; Kunkler, Ian H.; Langdon, Simon (2017) - Journal article
    Hypoxic cancer cells exhibit resistance to many therapies. This study compared the therapeutic effect of targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions, ...
  • Multi-scale genomic, transcriptomic and proteomic analysis of colorectal cancer cell lines to identify novel biomarkers 

    Briffa, Romina; Um, In Hwa; Faratian, Dana; Zhou, Ying; Turnbull, Arran K; Langdon, Simon P; Harrison, David James (2015-12-17) - Journal article
    Selecting colorectal cancer (CRC) patients likely to respond to therapy remains a clinical challenge. The objectives of this study were to establish which genes were differentially expressed with respect to treatment ...
  • Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting 

    Caie, Peter David; Zhou, Ying; Turnbull, Arran; Oniscu, Anca; Harrison, David James (2016-06-15) - Journal article
    A number of candidate histopathologic factors show promise in identifying stage II colorectal cancer (CRC) patients at a high risk of disease-specific death, however they can suffer from low reproducibility and none have ...
  • A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells 

    Khalil, Hilal S.; Langdon, Simon P.; Goltsov, Alexey; Soininen, Tero; Harrison, David James; Brown, James; Deeni, Yusuf Y. (2016) - Journal article
    Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase is frequently overexpressed in cancers leading to ...
  • Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis 

    Verleyen, Wim; Langdon, Simon P; Faratian, Dana; Harrison, David James; Smith, V Anne (2015-10-27) - Journal article
    Current clinical practice in cancer stratifies patients based on tumour histology to determine prognosis. Molecular profiling has been hailed as the path towards personalised care, but molecular data are still typically ...
  • Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system 

    Koussounadis, Antonis; Langdon, Simon; Um, In Hwa; Harrison, David James; Smith, V Anne (2015-06-08) - Journal article
    Differential mRNA expression studies implicitly assume that changes in mRNA expression have biological meaning, most likely mediated by corresponding changes in protein levels. Yet studies into mRNA-protein correspondence ...
  • Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies 

    Van Neste, Leander; Partin, Alan W.; Stewart, Grant D.; Epstein, Jonathan I.; Harrison, David James; Van Criekinge, Wim (2016-09-01) - Journal article
    BACKGROUND. Prostate cancer (PCa) diagnosis is challenging because efforts for effective, timely treatment of men with significant cancer typically result in over-diagnosis and repeat biopsies. The presence or absence of ...
  • The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer 

    Huang, Rui; Langdon, Simon P.; Tse, Matthew; Mullen, Peter; Um, In Hwa; Faratian, Dana; Harrison, David James (2015-12-14) - Journal article
    Chromatin undergoes structural changes in response to extracellular and environmental signals. We observed changes in nuclear morphology in cancer tissue biopsied after chemotherapy and hypothesised that these DNA ...
  • A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery : SiViT 

    Brown, James L; Shovman, Mark; Robertson, Paul; Boiko, Andrei; Goltsov, Alexey; Mullen, Peter; Harrison, David James (2017-05) - Journal article
    Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the ...
  • Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer 

    Stewart, Grant D; O'Mahony, Fiach; Laird, Alexander; Eory, Lel; Lubbock, Alexander; Mackay, Alan; Nanda, Jyoti; O'Donnell, Marie; Mullen, Peter; McNeill, Alan; Riddick, Antony; Berney, Daniel; Bex, Axel; Aitchison, Michael; Overton, Ian M; Harrison, David James; Powles, Thomas (2015) - Journal article
    Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple ...
  • A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma 

    Gremel, Gabriela; Djureinovic, Dijana; Niinivirta, Marjut; Laird, Alexander; Ljungqvist, Oscar; Johannesson, Henrik; Bergman, Julia; Edqvist, Perk-Henrik; Navani, Sanjay; Khan, Naila; Patil, Tushar; Sivertsson, Åsa; Uhlén, Mathias; Harrison, David James; Ullenhag, Gustav J.; Stewart, Grant D.; Pontén, Fredrik (2017-01-04) - Journal article
    Background There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC). Methods Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and ...