St Andrews Research Repository

Showing items related by title, author, creator and subject.

• Novel cambinol analogues as potential anticancer agents : an improved understanding of sirtuin isoform selectivity 

  Medda, Federico (University of St Andrews, 2011-06-22) - Thesis

  SIRT1 and SIRT2 are two NAD⁺-dependent deacetylases which negatively modulate the activity of p53, a protein which is involved in cell cycle arrest, senescence and apoptosis following genotoxic stress. Part I of the thesis ...

• Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface 

  Mücke, Katrin; Paulus, Christina; Bernhardt, Katharina; Gerrer, Katrin; Schön, Kathrin; Fink, Alina; Sauer, Eva-Maria; Asbach-Nitzsche, Alexandra; Harwardt, Thomas; Kieninger, Bärbel; Kremer, Werner; Kalbitzer, Hans Robert; Nevels, Michael (2014-01) - Journal article

  The 72-kDa immediate early 1 (IE1) protein encoded by human cytomegalovirus (hCMV) is a nuclearly localized promiscuous regulator of viral and cellular transcription. IE1 has long been known to associate with host mitotic ...

• Combining SPR with atomic-force microscopy enables singlemolecule insights into activation and suppression of the complement cascade 

  Makou, Elisavet; Bailey, Richard G.; Johnston, Heather; Parkin, John D.; Hulme, Alison N.; Hähner, Georg; Barlow, Paul N. (2019-12-27) - Journal article

  Activation and suppression of the complement system compete on every serum-exposed surface, host or foreign. Potentially harmful outcomes of this competition depend on surface molecules through mechanisms that remain ...