St Andrews Research Repository

Showing items related by title, author, creator and subject.

• Synthesis, and spectroscopic and structural characterization of three new styrylquinoline–benzimidazole hybrids 

  Ardila, Diana M.; Rodriguez, Diego F.; Palma, Alirio; Diaz, Ivan; Cobo, Justo; Glidewell, Christopher (2022-11-01) - Journal article

  Three new 4-styryl­quinoline–benzimidazole hybrids have been synthesized using a reaction sequence in which 2-methyl­quinoline precursors first undergo selective oxidation by selenium dioxide to form the corresponding ...

• Novel cambinol analogues as potential anticancer agents : an improved understanding of sirtuin isoform selectivity 

  Medda, Federico (University of St Andrews, 2011-06-22) - Thesis

  SIRT1 and SIRT2 are two NAD⁺-dependent deacetylases which negatively modulate the activity of p53, a protein which is involved in cell cycle arrest, senescence and apoptosis following genotoxic stress. Part I of the thesis ...

• Under-dominance constrains the evolution of negative autoregulation in diploids 

  Stewart, Alexander J; Seymour, Robert M; Pomiankowski, Andrew; Reuter, Max (2013-03-21) - Journal article

  Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. Theoretical work and ...