Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy
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Burkholderia pseudomallei isolates with shared multilocus sequence types (STs) have not been isolated from different continents. We identified two STs shared between Australia and Cambodia. Whole-genome analysis revealed substantial diversity within STs, correctly identified the Asian or Australian origin, and confirmed that these shared STs were due to homoplasy.
De Smet , B , Sarovich , D S , Price , E P , Mayo , M , Theobald , V , Kham , C , Heng , S , Phe , T , Holden , M T G , Parkhill , J , Peacock , S J , Spratt , B G , Jacobs , J , Vandamme , P & Currie , B J 2015 , ' Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy ' , Journal of Clinical Microbiology , vol. 53 , no. 1 , pp. 323-326 . https://doi.org/10.1128/JCM.02574-14
Journal of Clinical Microbiology
Copyright © 2015, De Smet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/)
DescriptionWhole-genome sequencing of the four isolates used in this study was supported by Wellcome Trust grant 098051, awarded to the Wellcome Trust Sanger Institute. This work was also supported by project grants from the Australian National Health and Medical Research Council and the Wellcome Trust. S.J.P. receives funding from the NIHR Cambridge Biomedical Research Centre.
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