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Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)

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Holden_2010_Jbac_Genome.pdf (2.532Mb)
Date
02/2010
Author
Holden, Matthew T. G.
Lindsay, Jodi A.
Corton, Craig
Quail, Michael A.
Cockfield, Joshua D.
Pathak, Smriti
Batra, Rahul
Parkhill, Julian
Bentley, Stephen D.
Edgeworth, Jonathan D.
Keywords
Nucleotide-sequence
Evolution
Strain
Identification
Epidermidis
Virulence
Proteins
Clone
Gene
Chromosome
QR Microbiology
Metadata
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Abstract
The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions ( 635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.
Citation
Holden , M T G , Lindsay , J A , Corton , C , Quail , M A , Cockfield , J D , Pathak , S , Batra , R , Parkhill , J , Bentley , S D & Edgeworth , J D 2010 , ' Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW) ' , Journal of Bacteriology , vol. 192 , no. 3 , pp. 888-892 . https://doi.org/10.1128/JB.01255-09
Publication
Journal of Bacteriology
Status
Peer reviewed
DOI
https://doi.org/10.1128/JB.01255-09
ISSN
0021-9193
Type
Journal article
Rights
Copyright © 2010, American Society for Microbiology. All Rights Reserved. The authors have paid a fee to allow immediate free access to this article
Description
The Sanger Institute is core funded by the Wellcome Trust. Funding for the sequencing of the TW20 genome was provided by Guy’s and St. Thomas’ Charity. J.D.E. receives funding from the Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/4970

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