Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)

Holden, Matthew T. G.; Lindsay, Jodi A.; Corton, Craig; Quail, Michael A.; Cockfield, Joshua D.; Pathak, Smriti; Batra, Rahul; Parkhill, Julian; Bentley, Stephen D.; Edgeworth, Jonathan D.

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Date

02/2010

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Abstract

The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions ( 635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

Citation

Holden , M T G , Lindsay , J A , Corton , C , Quail , M A , Cockfield , J D , Pathak , S , Batra , R , Parkhill , J , Bentley , S D & Edgeworth , J D 2010 , ' Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW) ' , Journal of Bacteriology , vol. 192 , no. 3 , pp. 888-892 . https://doi.org/10.1128/JB.01255-09

Publication

Journal of Bacteriology

Status

Peer reviewed

DOI

https://doi.org/10.1128/JB.01255-09

ISSN

0021-9193

Type

Journal article

Rights

Description

The Sanger Institute is core funded by the Wellcome Trust. Funding for the sequencing of the TW20 genome was provided by Guy’s and St. Thomas’ Charity. J.D.E. receives funding from the Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London.

Collections

University of St Andrews Research

URI

http://hdl.handle.net/10023/4970