Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer
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Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.
Caie , P D , Turnbull , A K , Farrington , S M , Oniscu , A & Harrison , D J 2014 , ' Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer ' Journal of Translational Medicine , vol 12 , no. 1 , 156 . DOI: 10.1186/1479-5876-12-156
Journal of Translational Medicine
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Funding: University of St Andrews and NHS Lothian.
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