Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer
Abstract
Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.
Citation
Caie , P D , Turnbull , A K , Farrington , S M , Oniscu , A & Harrison , D J 2014 , ' Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer ' , Journal of Translational Medicine , vol. 12 , no. 1 , 156 . https://doi.org/10.1186/1479-5876-12-156
Publication
Journal of Translational Medicine
Status
Peer reviewed
ISSN
1479-5876Type
Journal article
Rights
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Description
Funding: University of St Andrews and NHS Lothian.Collections
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