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dc.contributor.authorCaie, Peter David
dc.contributor.authorTurnbull, Arran K
dc.contributor.authorFarrington, Susan M
dc.contributor.authorOniscu, Anca
dc.contributor.authorHarrison, David J
dc.identifier.citationCaie , P D , Turnbull , A K , Farrington , S M , Oniscu , A & Harrison , D J 2014 , ' Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer ' , Journal of Translational Medicine , vol. 12 , no. 1 , 156 .
dc.identifier.otherPURE: 127012413
dc.identifier.otherPURE UUID: dcf0ef88-bf14-4d85-bc32-922501073f64
dc.identifier.otherPubMed: 24885583
dc.identifier.otherScopus: 84904393656
dc.identifier.otherORCID: /0000-0002-0031-9850/work/60196561
dc.identifier.otherWOS: 000339025700001
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034351
dc.descriptionFunding: University of St Andrews and NHS Lothian.en
dc.description.abstractTumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.
dc.relation.ispartofJournal of Translational Medicineen
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.subjectImage analysisen
dc.subjectLymphatic vessel densityen
dc.subjectLymphatic vessel invasionen
dc.subjectTumour buddingen
dc.subjectDigital pathologyen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.titleQuantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal canceren
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.description.statusPeer revieweden

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