Medicine: Recent submissions

Now showing items 156-160 of 205

    • Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest 

      Sheahan, Sharon; Bellamy, Christopher O; Dunbar, Donald R; Harrison, David J; Prost, Sandrine (2007-11-19) - Journal article
      TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F ...

    • Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence 

      Faratian, Dana; Christiansen, Jason; Gustavson, Mark; Jones, Christine; Scott, Christopher; Um, InHwa; Harrison, David J (2011-10-25) - Journal article
      Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, ...

    • Long-term culture of human breast cancer specimens and their analysis using optical projection tomography 

      Leeper, Alexander D; Farrell, Joanne; Dixon, J Michael; Wedden, Sarah E; Harrison, David J; Katz, Elad (2011-07-29) - Journal article
      Breast cancer is a leading cause of mortality in the Western world. It is well established that the spread of breast cancer, first locally and later distally, is a major factor in patient prognosis. Experimental systems ...

    • Apoptosis and DNA methylation 

      Meng, Huan X; Hackett, James A; Nestor, Colm; Dunican, Donncha S; Madej, Monika; Reddington, James P; Pennings, Sari; Harrison, David J; Meehan, Richard R (2011-04-01) - Journal article
      Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone ...

    • Targeting of Rac GTPases blocks the spread of intact human breast cancer 

      Katz, Elad; Sims, Andrew H; Sproul, Duncan; Caldwell, Helen; Dixon, Mike; Meehan, Richard R; Harrison, David J (2012-06) - Journal article
      High expression of Rac small GTPases in invasive breast ductal carcinoma is associated with poor prognosis, but its therapeutic value in human cancers is not clear. The aim of the current study was to determine the response ...