Medicine: Recent submissions
Now showing items 151-155 of 205
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The role of CTCF in the life cycle of human papillomavirus
(University of St Andrews, 2014-06-27) - ThesisPapillomaviruses (PV) are epithelium specific DNA viruses that can cause health problems ranging from harmless warts to invasive cancer. Papillomavirus induced tumours most often arise in the cervix where human papillomavirus ... -
Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast
(1994-01) - Journal articleGlutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 ... -
Genetic and epigenetic analyses of MBD3 in colon and lung cancer
(2004-05-17) - Journal articleMBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our ... -
Adenovirus-mediated Cre deletion of floxed sequences in primary mouse cells is an efficient alternative for studies of gene deletion
(2001-08-15) - Journal articleThis study evaluates the utility of Cre-expressing adenovirus for deletion of floxed genes in primary cells using primary murine hepatocytes. Adenovirus infection was very efficient, even at very low MOI (>95% infection ... -
While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable
(2003-12) - Journal articleIn mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while ...