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Diversity of matriptase expression level and function in breast cancer

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Date
13/04/2012
Author
Welman, Arkadiusz
Sproul, Duncan
Mullen, Peter
Muir, Morwenna
Kinnaird, Andrew R.
Harrison, David J.
Faratian, Dana
Brunton, Valerie G.
Frame, Margaret C.
Keywords
Matriptase
Breast cancer
HER2 expression
Overexpression
E-cadherin
R Medicine
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Abstract
Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase expression in 16 human breast cancer cell lines and in 107 primary breast tumors. The data revealed considerable diversity in the expression level of this protein indicating that the significance of matriptase may vary from case to case. Matriptase protein expression was correlated with HER2 expression and highest expression was seen in HER2-positive cell lines, indicating a potential role in this subgroup. Stable overexpression of matriptase in two breast cancer cell lines had different consequences. In MDA-MB-231 human breast carcinoma cells the only noted consequence of matriptase overexpression was modestly impaired growth in vivo. In contrast, overexpression of matriptase in 4T1 mouse breast carcinoma cells resulted in visible changes in morphology, actin staining and cell to cell contacts. This correlated with downregulation of the cell-cell adhesion molecule E-cadherin. These results suggest that the functions of matriptase in breast cancer are likely to be variable and cell context dependent.
Citation
Welman , A , Sproul , D , Mullen , P , Muir , M , Kinnaird , A R , Harrison , D J , Faratian , D , Brunton , V G & Frame , M C 2012 , ' Diversity of matriptase expression level and function in breast cancer ' , PLoS One , vol. 7 , no. 4 , e34182 . https://doi.org/10.1371/journal.pone.0034182
Publication
PLoS One
Status
Peer reviewed
DOI
https://doi.org/10.1371/journal.pone.0034182
ISSN
1932-6203
Type
Journal article
Rights
© 2012 Welman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description
This work was funded by Cancer Research UK Program Grant (C157/A9148).
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/4149

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